2,6-双[(2R,4S,5S)-1-苄基-4,5-二苯基咪唑烷-2-基]吡啶 | 1223020-29-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 2,6-双[(2R,4S,5S)-1-苄基-4,5-二苯基咪唑烷-2-基]吡啶
• 英文名称: 2,6-bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine
• 英文别名: (S,S)-PyBidine
• CAS: 1223020-29-8
• 化学式: C₄₉H₄₅N₅
• 分子量: 703.93
• InChiKey: XLWFDEFJSJPDND-CTRFHGHOSA-N

物化性质

• 密度：
  1.178±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  54
• 可旋转键数：
  10
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  43.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-双[(2R,4S,5S)-1-苄基-4,5-二苯基咪唑烷-2-基]吡啶 、 nickel dichloride 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 C₄₉H₄₅ClN₅Ni⁽¹⁺⁾*Cl^(1-)
  参考文献：
  名称：

  Bis(imidazolidine)pyridine-NiCl₂ Catalyst for Nitro-Mannich Reaction of Isatin-Derived N-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles

  摘要：

  An (S,S)-diphenyldiamine-derived bis(imidazolidine)-pyridine (PyBidine)-NiCl2 complex catalyzed the nitro-Mannich reaction of isatin-derived N-Boc ketimines to construct a chiral quaternary aminocarbon center at the C3 position of oxindoles in yields of up to 99% with 95% ee.

  DOI：

  10.1021/ol501085y
• 作为产物：
  描述：

  吡啶-2,6-二甲醛 、 (1S,2S)-N1-苄基-1,2-二苯乙烷-1,2-二胺 在 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 生成 2,6-双[(2R,4S,5S)-1-苄基-4,5-二苯基咪唑烷-2-基]吡啶
  参考文献：
  名称：

  Chiral Bis(imidazolidine)pyridine−Cu(OTf)₂: Catalytic Asymmetric Endo-Selective [3 + 2] Cycloaddition of Imino Esters with Nitroalkenes

  摘要：

  The novel C-2-symmetric bis(imidazolidine)pyridine (PyBidine) ligand was easily synthesized in a single condensation of 2,6-pyridyl aldehyde and optically active (S,S)diphenylethylenediamine. In the C-2-symmetric PyBidine-Cu(OTf)(2) complex, imidazolidine rings act as "chiral fences" to shield the first and third quadrants. Use of the PyBidine-Cu(OTf)(2) complex as a catalyst enabled the highly endo-selective reaction of imino esters and nitroalkenes to give the adducts in up to 99% ee.

  DOI：

  10.1021/ja100265j
• 作为试剂：
  描述：

  2-乙烯基-1H-吲哚 、 1-Nitro-4-phenyl-butadien 在 nickel(II) triflate 、 2,6-双[(2R,4S,5S)-1-苄基-4,5-二苯基咪唑烷-2-基]吡啶 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 18.0h， 以33%的产率得到
  参考文献：
  名称：

  Friedel-Crafts反应催化不对称合成手性2-乙烯基吲哚骨架

  摘要：

  手性双（咪唑烷）吡啶（PyBidine）-Ni（OTf）2配合物可平稳催化2-乙烯基吲哚与硝基烯烃的不对称Friedel-Crafts反应，从而以高对映选择性的方式提供手性吲哚，同时保持2-乙烯基官能度。手性2-乙烯基吲哚提供了独特的手性支架，可以进行多种转化。

  DOI：

  10.1021/acs.orglett.6b03584

文献信息

• PyBidine–Ni(OAc)₂-Catalyzed Michael/Aldol Reaction of Methyleneindolinones and Thiosalicylaldehydes for Stereochemically Divergent Thiochromanyl-spirooxindoles
  作者：Takayoshi Arai、Tomoya Miyazaki、Hiroki Ogawa、Hyuma Masu

  DOI：10.1021/acs.orglett.6b02783

  日期：2016.11.18

  (S,S)-Diphenylethylenediamine-derived bis(imidazolidine)pyridine (PyBidine)–Ni(OAc)2 complex catalyzed the asymmetric Michael/aldol reaction of methyleneindolinone and thiosalicylaldehyde to produce (2′R,3S,4′R)-thiochromanyl-spirooxindole having three contiguous stereogenic centers.

  （小号，小号）-Diphenylethylenediamine衍生的双（咪唑）吡啶（PyBidine）-Ni（OAC）2络合物催化不对称迈克尔加成/ methyleneindolinone和thiosalicylaldehyde的醛醇缩合反应以制备（2' - [R，3小号，4' - [R ）-具有三个连续的立体异构中心的硫代苯并二氢吡喃恶螺。
• RESIN COMPOSITION, LAMINATE, RESIN COMPOSITION LAYER-ATTACHED SEMICONDUCTOR WAFER, SUBSTRATE FOR MOUNTING RESIN COMPOSITION LAYER-ATTACHED SEMICONDUCTOR, AND SEMICONDUCTOR DEVICE
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP3786200A1

  公开（公告）日：2021-03-03

  A resin composition that has excellent flux activity, flexibility and storage stability and that is suitable for a pre-applied underfill material is provided. The resin composition of the present invention contains a compound (A) having a phenolic hydroxy group, a metal ion trapping agent (B) and a radical polymerizable compound (C).

  本发明提供了一种树脂组合物，该树脂组合物具有优异的通量活性、柔韧性和贮存稳定性，适用于预涂敷的底部填充材料。本发明的树脂组合物含有一种具有酚羟基的化合物（A）、一种金属离子捕获剂（B）和一种可自由基聚合的化合物（C）。
• Bis(imidazolidine)pyridine-NiCl₂ Catalyst for Nitro-Mannich Reaction of Isatin-Derived <i>N</i>-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles
  作者：Takayoshi Arai、Eri Matsumura、Hyuma Masu

  DOI：10.1021/ol501085y

  日期：2014.5.16

  An (S,S)-diphenyldiamine-derived bis(imidazolidine)-pyridine (PyBidine)-NiCl2 complex catalyzed the nitro-Mannich reaction of isatin-derived N-Boc ketimines to construct a chiral quaternary aminocarbon center at the C3 position of oxindoles in yields of up to 99% with 95% ee.
• NOVEL COMPOUND AND ANTIVIRAL AGENT CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY

  公开号：US20170368015A1

  公开（公告）日：2017-12-28

  An object of the invention is to provide a compound that can be utilized as an antiviral agent, in particular as an anti-RNA viral agent, and especially as an anti-RS viral agent. The invention provides a compound indicated by Formula (1), wherein R1 each independently represent hydrogen, halogen, hydroxyl, amino, carboxyl, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 halogenoalkyl, C1-C6 alkoxycarbonyl, C1-C6 alkylamino, C2-C5 alkenyl, C3-C6 cycloalkyl, or optionally substituted aryl; R2 each independently represent hydrogen, C1-C6 alkyl, C1-C6 halogenoalkyl, C2-C5 alkenyl, C3-C6 cycloalkyl, optionally substituted aryl or heterocyclic group; and one or more R1 may be present in the same ring, an isomer thereof, a pharmaceutically acceptable salt thereof, or a mixture of these. The compounds provided by the invention are useful as drugs for the prevention or treatment of infectious diseases by virus, especially RS virus, and in particular infectious diseases in the lower airways (e.g., bronchiolitis, pneumonia, etc.).
• RESIN COMPOSITION, LAMINATE, SEMICONDUCTOR WAFER WITH RESIN COMPOSITION LAYER, SUBSTRATE FOR MOUNTING SEMICONDUCTOR WITH RESIN COMPOSITION LAYER AND SEMICONDUCTOR DEVICE
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20210277221A1

  公开（公告）日：2021-09-09

  A resin composition that has excellent flux activity, flexibility and storage stability and that is suitable for a pre-applied underfill material is provided. The resin composition contains a compound (A) having a phenolic hydroxy group, a metal ion trapping agent (B) and a radical polymerizable compound (C).