2-(2-吗啉-4-基乙基)-6,7-二氢-5-氧杂-1,2-二氮杂二苯并[cd,f]薁-3(2H)-酮 | 219667-00-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 中文名称: 2-(2-吗啉-4-基乙基)-6,7-二氢-5-氧杂-1,2-二氮杂二苯并[cd,f]薁-3(2H)-酮
• 英文名称: (-)-(6S)-6-hydroxy-5,6,7,8-tetrahydroindolizine
• 英文别名: (S)-5,6,7,8-Tetrahydroindolizin-6-ol；(6S)-5,6,7,8-tetrahydroindolizin-6-ol
• CAS: 219667-00-2
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: ODBPVBCCCHVXKY-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (+)-(αR,1R,4S)-2-(α-phenylethyl)-1,2,4,5-tetrahydro-1.4-methanopyrrolo<2,1-d><1,2,5>oxadiazepine 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以65%的产率得到2-(2-吗啉-4-基乙基)-6,7-二氢-5-氧杂-1,2-二氮杂二苯并[cd,f]薁-3(2H)-酮
  参考文献：
  名称：

  Intramolecular Cycloadditions of Nitrones Derived from 1-Allyl-2-pyrrolecarbaldehyde as a Route to Racemic and Enantiopure Pyrrolizidines and Indolizidines

  摘要：

  A version of the intramolecular nitrone cycloaddition strategy, using 2-pyrrolecarbaldehyde as starting material, has been developed to synthesize new pyrrolizidines and indolizidines structurally related to biologically active alkaloids. The target molecules have been accessible in racemic as well as enantiopure form.

  DOI：

  10.1021/jo9810415

文献信息

• Intramolecular Cycloadditions of Nitrones Derived from 1-Allyl-2-pyrrolecarbaldehyde as a Route to Racemic and Enantiopure Pyrrolizidines and Indolizidines
  作者：Alberto Arnone、Gianluigi Broggini、Daniele Passarella、Alberto Terraneo、Gaetano Zecchi

  DOI：10.1021/jo9810415

  日期：1998.12.1

  A version of the intramolecular nitrone cycloaddition strategy, using 2-pyrrolecarbaldehyde as starting material, has been developed to synthesize new pyrrolizidines and indolizidines structurally related to biologically active alkaloids. The target molecules have been accessible in racemic as well as enantiopure form.