2-(2-氯-5-甲基苯甲酰)苯甲酸 | 71550-20-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2-氯-5-甲基苯甲酰)苯甲酸
• 英文名称: 2-(2'-chloro-5'-methylbenzoyl)benzoic acid
• 英文别名: 2-(2-chloro-5-methyl-benzoyl)-benzoic acid；2-(2-Chlor-5-methyl-benzoyl)-benzoesaeure；6'-Chlor-3'-methyl-benzophenon-carbonsaeure-(2)；6'-Chlor-3'-methyl-benzophenon-cabonsaeure-(2)；2-(2'-Chlor-5'-methylbenzoyl)-benzoesaeure；Benzoic acid, 2-(2-chloro-5-methylbenzoyl)-；2-(2-chloro-5-methylbenzoyl)benzoic acid
• CAS: 71550-20-4
• 化学式: C₁₅H₁₁ClO₃
• 分子量: 274.704
• InChiKey: OACHMRGCIDBGJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-氯-5-甲基苯甲酰)苯甲酸 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and blood glucose lowering activity of some novel benzenesulfonylthiourea derivatives substituted with 4-aryl-1-oxophthalazin-2(1H)yl-ones

  摘要：

  Some new benzenesulfonylthiourea derivatives substituted with phthalazones (2a-q) were synthesized by refluxing the appropriate 4-aryl-1-oxophthalazin-2(1H)yl benzenesulfonamides with isothiocyanate in dry acetone over anhydrous K2CO3. All the synthesized compounds were characterized on the basis of IR, H-1 NMR, MS data and elemental analysis. These synthesized compounds (2a-q) at the dose of 20 mg/kg were tested for antihyperglycemic activity in the glucose-fed hyperglycemic normal rat model and among these compounds 2f and 2m showed modest antihyperglycemic activity.

  DOI：

  10.3109/14756366.2013.782300
• 作为产物：
  描述：

  苯酐 、 对氯甲苯 在 aluminum (III) chloride 作用下， 生成 2-(2-氯-5-甲基苯甲酰)苯甲酸
  参考文献：
  名称：

  Synthesis and blood glucose lowering activity of some novel benzenesulfonylthiourea derivatives substituted with 4-aryl-1-oxophthalazin-2(1H)yl-ones

  摘要：

  Some new benzenesulfonylthiourea derivatives substituted with phthalazones (2a-q) were synthesized by refluxing the appropriate 4-aryl-1-oxophthalazin-2(1H)yl benzenesulfonamides with isothiocyanate in dry acetone over anhydrous K2CO3. All the synthesized compounds were characterized on the basis of IR, H-1 NMR, MS data and elemental analysis. These synthesized compounds (2a-q) at the dose of 20 mg/kg were tested for antihyperglycemic activity in the glucose-fed hyperglycemic normal rat model and among these compounds 2f and 2m showed modest antihyperglycemic activity.

  DOI：

  10.3109/14756366.2013.782300

文献信息

• Castle, Raymond N.; Kudo, Hirotaka; Lee, Milton L., Collection of Czechoslovak Chemical Communications, 1991, vol. 56, # 11.1, p. 2269 - 2277
  作者：Castle, Raymond N.、Kudo, Hirotaka、Lee, Milton L.

  DOI：——

  日期：——
• Mellier, Annales de Chimie (Cachan, France), 1955, vol. <12> 10, p. 666,682
  作者：Mellier

  DOI：——

  日期：——
• Mehendale, Indian Journal of Chemistry, 1979, vol. 17 B, p. 400
  作者：Mehendale

  DOI：——

  日期：——
• MEHENDALE A. R., INDIAN J. CHEM., 1979, B 17, NO 4, 400-401
  作者：MEHENDALE A. R.

  DOI：——

  日期：——
• Synthesis and blood glucose lowering activity of some novel benzenesulfonylthiourea derivatives substituted with 4-aryl-1-oxophthalazin-2(1H)yl-ones
  作者：Shafiya Yaseen、Rafia Bashir、Syed Ovais、Pooja Rathore、Mohammed Samim、Kalim Javed

  DOI：10.3109/14756366.2013.782300

  日期：2014.6.1

  Some new benzenesulfonylthiourea derivatives substituted with phthalazones (2a-q) were synthesized by refluxing the appropriate 4-aryl-1-oxophthalazin-2(1H)yl benzenesulfonamides with isothiocyanate in dry acetone over anhydrous K2CO3. All the synthesized compounds were characterized on the basis of IR, H-1 NMR, MS data and elemental analysis. These synthesized compounds (2a-q) at the dose of 20 mg/kg were tested for antihyperglycemic activity in the glucose-fed hyperglycemic normal rat model and among these compounds 2f and 2m showed modest antihyperglycemic activity.