2-(2-氯乙氧基)-1,3-二甲氧基苯 | 24251-50-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2-氯乙氧基)-1,3-二甲氧基苯
• 英文名称: 2-(2,6-dimethoxyphenoxy)ethyl chloride
• 英文别名: 2-(2-Chloroethoxy)-1,3-dimethoxybenzene
• CAS: 24251-50-1
• 化学式: C₁₀H₁₃ClO₃
• 分子量: 216.664
• InChiKey: QJLAEVDWQPIZHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  2-(2-氯乙氧基)-1,3-二甲氧基苯 以 乙醇 、 异戊醇 为溶剂， 反应 76.0h， 生成 2-N-[2-(2,6-dimethoxyphenoxy)ethyl]-6,7-dimethoxy-2-N-methylquinazoline-2,4-diamine
  参考文献：
  名称：

  Structure-activity relationships for prazosin and WB 4101 analogs as .alpha.1-adrenoreceptor antagonists

  摘要：

  Several alpha-adrenoreceptor antagonists were prepared by coupling one of the two moieties of WB 4101 (1) with one of the two moieties of prazosin (2). Their blocking activity and relative selectivity on alpha 1- and alpha 2-adrenoreceptors were evaluated in the isolated rat vas deferens. Although retaining a significant selectivity toward alpha 1-adrenoreceptors, all the drugs were weaker antagonists than the parent compounds 1 and 2. Opening the piperazine ring of 2 gave 3, which displayed a very high activity and selectivity toward alpha 1-adrenoreceptors (alpha 1/alpha 2 = 3890). This may have relevance in understanding the mode of action of prazosin. In addition, 3 may represent a valuable tool in the characterization of alpha-adrenoreceptor subtypes.

  DOI：

  10.1021/jm00147a042
• 作为产物：
  描述：

  2-(2,6-二甲氧基苯氧基)乙醇 生成 2-(2-氯乙氧基)-1,3-二甲氧基苯
  参考文献：
  名称：

  TOMIYAMA, TSUYOSHI;UEYAMA, NAOTO;ICHIKAWA, YUMIKO

  摘要：

  DOI：

文献信息

• Antihypertensive 1,5-benzothiazepine derivatives and compositions thereof
  申请人：Kotokuki Seiya Kau Co., Ltd.

  公开号：US04780462A1

  公开（公告）日：1988-10-25

  A new series of 1,5-benzothiazepine analogues are disclosed. These compounds are represented by the following general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrogen, a lower alkyl, nitro, amino, lower-alkyl-oxy or halogen group, X represents O or S. These compounds are useful as anti-hypertensive agents.

  公开了一种新的1,5-苯并噻吩类似物系列。这些化合物由以下通用式表示：##STR1##其中R.sub.1、R.sub.2和R.sub.3分别表示氢、较低的烷基、硝基、氨基、较低烷氧基或卤素基，X表示O或S。这些化合物可用作降压剂。
• Some Cardiovascular Effects of a Series of Aryloxyalkylamines. II¹
  作者：J. Augstein、W. C. Austin、C. A. Bartram、R. J. Boscott

  DOI：10.1021/jm00324a004

  日期：1966.11
• Ferri; Pallavicini; Piccini, Farmaco, Edizione Scientifica, 1988, vol. 43, # 12 SUPPL., p. 1153 - 1163
  作者：Ferri、Pallavicini、Piccini、Valoti、Villa

  DOI：——

  日期：——
• Dewar; Kapur; Mottram, European Journal of Medicinal Chemistry, 1983, vol. 18, # 3, p. 286 - 290
  作者：Dewar、Kapur、Mottram

  DOI：——

  日期：——
• GIARDINA, D.;BERTINI, R.;BRANCIA, E.;BRASILI, L.;MELCHIORRE, C., J. MED. CHEM., 1985, 28, N 9, 1354-1357
  作者：GIARDINA, D.、BERTINI, R.、BRANCIA, E.、BRASILI, L.、MELCHIORRE, C.

  DOI：——

  日期：——