(2S)-2-chlorobutanedioyl dichloride

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: (2S)-2-chlorobutanedioyl dichloride
• 化学式: C₄H₃Cl₃O₂
• 分子量: 189.42
• InChiKey: ZKASOSSCYHQHDU-REOHCLBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for preparing R-(-)carnitine from S-(-)-chlorosuccinic acid or from a derivative thereof
  申请人：Melloni Piero

  公开号：US20050245762A1

  公开（公告）日：2005-11-03

  An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formula (I): where X 1 and X 2 , which may be the same or different, are hydroxy, C 1 -C 4 alkoxy, phenoxy, halogen, or X 1 and X 2 , when taken together are an oxygen atom and the resulting compound is a derivative of succinic anhydride; Y is halogen, a mesyloxy or a tosyloxy group, and subsequent treatment with water, then with a base and then with trimethylamine.

  一种L-肉碱的内盐是通过还原配有适当还原剂的化合物(I)制备而成，其中X1和X2可以相同也可以不同，是羟基、C1-C4烷氧基、苯氧基、卤素，或者X1和X2结合在一起是氧原子，所得化合物是琥珀酐的衍生物；Y是卤素、甲烷磺氧基或对甲苯磺氧基，然后用水处理，接着用碱和三甲胺处理。
• Process for preparing R-(-)-carnitin from S-(-)-chlorosuccinic acid or from a derivative thereof
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：US20040102645A1

  公开（公告）日：2004-05-27

  An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formula (I): 1 where X 1 and X 2 , which may be the same or different, are hydroxy, C 1 -C 4 alkoxy, phenoxy, halogen, or X 1 and X 2 , when taken together are an oxygen atom and the resulting compound is a derivative of succinic anhydride; Y is halogen, a mesyloxy or a tosyloxy group, and subsequent treatment with water, then with a base and then with trimethylamine.

  一种L-肉碱内盐的制备方法，通过使用适当的还原剂还原式(I)的化合物制备，其中X1和X2可以相同也可以不同，是羟基、C1-C4烷氧基、苯氧基、卤素，或者当X1和X2在一起时，是氧原子，得到的化合物是琥珀酸酐的衍生物；Y是卤素、甲烷磺氧基或对甲苯磺酰氧基，然后用水、碱和三甲胺进行后续处理。
• PROCESS FOR PREPARING R-(-)-CARNITINE FROM S-(-)-CHLOROSUCCINIC ACID OR FROM A DERIVATIVE THEREOF
  申请人：SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP1187805B1

  公开（公告）日：2006-11-29
• US6677476B1
  申请人：——

  公开号：US6677476B1

  公开（公告）日：2004-01-13
• US6984739B2
  申请人：——

  公开号：US6984739B2

  公开（公告）日：2006-01-10