8-methoxy-1-methyl-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazol-7-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 8-methoxy-1-methyl-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazol-7-amine
• 化学式: C₁₂H₁₆N₄O
• 分子量: 232.28
• InChiKey: OCOMFCBAQQKBTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  56.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Inhibitors of polyq-aggregation
  申请人：Bottcher Henning

  公开号：US20050124631A1

  公开（公告）日：2005-06-09

  Compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 and R 5 have the meanings as given in claim 1, and their pharmaceutically tolerable derivatives, solvates and stereoisomers and their use for the preparation of a pharmaceutical for inhibiting the formation of polyQ-aggregation.

  公式I的化合物，其中R1，R2，R3，R4和R5具有声明1中所给定的含义，以及它们的药物可耐受衍生物，溶剂合物和立体异构体，并用于制备用于抑制聚Q聚集物形成的药物。
• INHIBITORS OF POLYQ-AGGREGATION
  申请人：BOTTCHER HENNING

  公开号：US20070259887A1

  公开（公告）日：2007-11-08

  Compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 and R 5 have the meanings as given in claim 1 , and their pharmaceutically tolerable derivatives, solvates and stereoisomers and their use for the preparation of a pharmaceutical for inhibiting the formation of polyQ-aggregation.

  公式I的化合物，其中R1、R2、R3、R4和R5的含义如权利要求1所述，并且它们的药学可耐受衍生物、溶剂合物和立体异构体以及它们的用途用于制备用于抑制聚Q聚集体形成的制药品。
• [EN] INHIBITORS OF POLYQ-AGGREGATION<br/>[FR] INHIBITEURS DE POLYQ-AGREGATION
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2003015772A1

  公开（公告）日：2003-02-27

  Compounds of formula I, wherein R?1, R2, R3, R4 and R5¿ have the meanings as given in claim 1, and their pharmaceutically tolerable derivatives, solvates and stereoisomers and their use for the preparation of a pharmaceutical for inhibiting the formation of polyQ-aggregation.