2-(3,4-二氯苯氧基)丙酰肼 | 588673-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(3,4-二氯苯氧基)丙酰肼
• 英文名称: 3,4-dichlorophenoxypropionic acid hydrazide
• 英文别名: 2-(3,4-Dichlorophenoxy)propanohydrazide；2-(3,4-dichlorophenoxy)propanehydrazide
• CAS: 588673-62-5
• 化学式: C₉H₁₀Cl₂N₂O₂
• mdl: MFCD00210182
• 分子量: 249.097
• InChiKey: QRDXUCWCNIUPTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  2-(3,4-二氯苯氧基)丙酰肼 、 间硝基苯甲醛 在 盐酸 作用下， 以 水 为溶剂， 反应 6.0h， 以75%的产率得到2-(3,4-dichlorophenoxy)-N'-(3-nitrobenzylidene)propanehydrazide
  参考文献：
  名称：

  Synthesis of Potential Biologically Active Compounds Based on Aryloxy- and Arylaminopropanehydrazides

  摘要：

  New derivatives of a number of aryloxy and arylaminopropanehydrazides were synthesized. Their heterocyclization under the action of carbon disulfide and potassium hydroxide and subsequent alkylation of the resulting 2-thioxo-1,3,4-oxadiazole ring, the corresponding S-substituted products were obtained. The reaction of the starting hydrazides with arylaldehydes and pentane-2,4-dione afforded theirN '-arylidene and N '-(4-oxopentan-2-ylidene) derivatives. In preliminary laboratory tests, the synthesized compounds showed a pronounced stimulating effect on plant growth. Their activity was 44-95% compared with heteroauxin.

  DOI：

  10.1134/s1070363220070014

文献信息

• A Facile One-Pot Synthesis of 2-Arylamino-5-Aryloxylalkyl-1,3,4-Oxadiazoles and Their Urease Inhibition Studies
  作者：Tashfeen Akhtar、Muhammad A. Khan、Jamshed Iqbal、Peter G. Jones、Shahid Hameed

  DOI：10.1111/cbdd.12297

  日期：2014.7

  A one‐pot method for the synthesis of structural type urease inhibitors, 2‐amino‐1,3,4‐oxadiazoles, was developed. The structures of the compounds were established using spectroanalytical techniques and unambiguously confirmed by single‐crystal X‐ray analysis of compound 3o. The synthesized compounds were tested against jack beans urease, and most of the compounds (3c, 3g, 3j, 3k, 3n, 3r–3v) were found more active than the standard. The most potent compound (3u) had an IC50 value of 6.03 ± 0.02 μm as compared to the IC50 value of the standard (thiourea; 22.0 ± 1.2 μm). The prominent urease inhibition activity of these compounds may serve as an important finding in the development of less toxic and more potent antiulcer drugs. The compounds were also investigated against four bacterial strains, and some of the compounds (3g and 3r) were found more potent than the standard drug (ciprofloxacin) against all the tested strains. The MIC value for compound 3g was 0.156 μmol/mL against the tested bacterial strains.
• Synthesis of Potential Biologically Active Compounds Based on Aryloxy- and Arylaminopropanehydrazides
  作者：T. A. Gomktsyan、R. S. Shainova、A. V. Karapetyan、A. P. Yengoyan

  DOI：10.1134/s1070363220070014

  日期：2020.7

  New derivatives of a number of aryloxy and arylaminopropanehydrazides were synthesized. Their heterocyclization under the action of carbon disulfide and potassium hydroxide and subsequent alkylation of the resulting 2-thioxo-1,3,4-oxadiazole ring, the corresponding S-substituted products were obtained. The reaction of the starting hydrazides with arylaldehydes and pentane-2,4-dione afforded theirN '-arylidene and N '-(4-oxopentan-2-ylidene) derivatives. In preliminary laboratory tests, the synthesized compounds showed a pronounced stimulating effect on plant growth. Their activity was 44-95% compared with heteroauxin.