2-(3,5-二氯苯基)环氧乙烷 | 78982-97-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(3,5-二氯苯基)环氧乙烷
• 英文名称: 2-(3,5-dichlorophenyl)oxirane
• CAS: 78982-97-5
• 化学式: C₈H₆Cl₂O
• 分子量: 189.041
• InChiKey: PUIRZUUEOCYTBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(3,5-二氯苯基)环氧乙烷 以 二氯甲烷 为溶剂， 生成 N-[[4-[[cyclobutyl-[2-(3,5-dichlorophenyl)-2-hydroxyethyl]carbamoyl]amino]phenyl]methyl]-2,2-dimethylpropanamide
  参考文献：
  名称：

  Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists

  摘要：

  Thrombin is the most potent agonist of platelet activation, and its effects are predominantly mediated by platelet thrombin receptors. Therefore, antagonists of the thrombin receptor have potential utility for the treatment of thrombotic disorders. Screening of combinatorial libraries revealed 2 to be a potent antagonist of the thrombin receptor. Modifications of this structure produced 11k, which inhibits thrombin receptor stimulated secretion and aggregation of platelets. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00538-8
• 作为产物：
  描述：

  1,3-二氯-5-乙烯基苯 以80 %的产率得到2-(3,5-二氯苯基)环氧乙烷
  参考文献：
  名称：

  AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS

  摘要：

  本发明涉及式(I)的化合物：或其药用盐，尤其用作ERK蛋白激酶的抑制剂，尤其是在ERK2活性方面的抑制剂。

  公开号：

  EP4212531A1

文献信息

• [EN] SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF<br/>[FR] BENZAMIDES SUBSTITUÉS ET LEURS MÉTHODES D'UTILISATION
  申请人：GENENTECH INC

  公开号：WO2015078374A1

  公开（公告）日：2015-06-04

  The invention provides compounds having the general formula I, and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

  这项发明提供了具有一般式I的化合物及其药用盐，其中变量RA、RAA、下标n、环A、X2、L、下标m、X1、R1、R2、R3、R4、R5和RN的含义如本文所述，并包含这种化合物的组合物和使用这种化合物和组合物的方法。
• Phenylethanolamine derivatives and acid addition salts thereof for
  申请人：American Cyanamid Company

  公开号：US04404222A1

  公开（公告）日：1983-09-13

  There is provided a method for enhancing the growth rate of meat-producing animals and/or improving the efficiency of feed utilization thereby, which involves, orally or parenterally, administering to said animals a growth-enhancing amount of a phenylethane compound or the acid addition salt thereof.

  提供了一种增强肉类生产动物生长速度和/或提高饲料利用效率的方法，包括口服或静脉注射给这些动物一种苯乙烷化合物或其酸加成盐，以增强生长。
• Phenylethanolamine derivatives and acid addition salts thereof for the
  申请人：American Cyanamid Company

  公开号：US04407819A1

  公开（公告）日：1983-10-04

  There is provided a method for increasing lean meat deposition and/or improving lean meat to fat ratio in poultry, domestic pets, sheep, swine, rabbits, goats and cattle by administering, orally or parenterally, to said animals an effective amount of a phenylethane derivative or acid salt thereof.

  提供了一种方法，通过给家禽、家养宠物、绵羊、猪、兔、山羊和牛口服或注射苯乙烷衍生物或其酸盐的有效剂量，以增加瘦肉沉积和/或改善瘦肉与脂肪的比例。
• Phenylethane derivatives and acid addition salts thereof for increasing
  申请人：American Cyanamid Company

  公开号：US04522822A1

  公开（公告）日：1985-06-11

  There is provided a method for increasing lean meat deposition and/or improving lean meat to fat ratio in poultry, domestic pets, sheep, swine, rabbits, goats and cattle by administering, orally or parenterally, to said animals an effective amount of a phenylethane derivative or acid salt thereof.

  提供了一种方法，通过给家禽、家养宠物、绵羊、猪、兔、山羊和牛口服或注射苯乙烷衍生物或其酸盐的有效量，来增加瘦肉沉积和/或改善瘦肉与脂肪的比例。
• SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF
  申请人：GENENTECH, INC.

  公开号：US20150252038A1

  公开（公告）日：2015-09-10

  The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R A , R AA , subscript n, ring A, X 2 , L, subscript m, X 1 , R 1 , R 2 , R 3 , R 4 , R 5 , and R N have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compactions.

  本发明提供具有一般式I的化合物及其药学上可接受的盐，其中变量RA、RAA、下标n、环A、X2、L、下标m、X1、R1、R2、R3、R4、R5和RN的含义如本文所述，并且包含这些化合物的组合物和使用这些化合物和组合物的方法。