2-(3-吡啶基甲基)-1-吡咯啉 | 106366-21-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(3-吡啶基甲基)-1-吡咯啉
• 英文名称: 2-(3-pyridylmethyl)-1-pyrroline
• 英文别名: 3-(3,4-dihydro-2H-pyrrol-5-ylmethyl)pyridine
• CAS: 106366-21-6
• 化学式: C₁₀H₁₂N₂
• 分子量: 160.219
• InChiKey: JFIQBEUJBAMIHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3-吡啶基甲基)-1-吡咯啉 在 盐酸 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 10.0h， 以89.4%的产率得到3-(吡咯烷-2-甲基)吡啶
  参考文献：
  名称：

  Secor, Henry V.; Seeman, Jeffrey I., Heterocycles, 1986, vol. 24, # 6, p. 1687 - 1698

  摘要：

  DOI：
• 作为产物：
  描述：

  3-吡啶乙酸乙酯 在 盐酸 、 lithium diisopropyl amide 作用下， 反应 40.25h， 生成 2-(3-吡啶基甲基)-1-吡咯啉
  参考文献：
  名称：

  Secor, Henry V.; Seeman, Jeffrey I., Heterocycles, 1986, vol. 24, # 6, p. 1687 - 1698

  摘要：

  DOI：

文献信息

• Novel analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders
  申请人：Buccafusco J. Jerry

  公开号：US20050227993A1

  公开（公告）日：2005-10-13

  The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease, Alzheimer's disease and related disorders such as amyotrophic lateral sclerosis, spinal muscular atrophy, Friedrich's ataxia, Pick's disease, Bassen-Kornzweig syndrome, Refsom's disease, retinal degeneration, Cruetzfelt-Jacob syndrome or prion disease (mad cow disease), dementia with Lewy bodies, schizophrenia, paraneoplastic cerebellar degeneration and neurodegenerative conditions caused by stroke. The present compounds are effective to treat any neurological condition where acetylcholine transmission neurons and their target cells are affected. Compounds according to the present invention are effective to alleviate and/or reverse the effects of a neurodegenerative condition, prevent further deterioration and/or enhance cognition and memory in patients suffering from neurodegenerative disorders, especially Alzheimer's disease.

  本发明涉及新型胆碱类似物以及使用或治疗神经退行性疾病和/或病症的方法，如帕金森病、亨廷顿病、阿尔茨海默病和相关疾病，如肌萎缩性脊髓侧索硬化症、脊髓性肌萎缩症、弗里德里希共济失调、皮克病、巴森-科恩茨韦格综合征、雷夫索姆病、视网膜变性、克鲁茨费尔特-雅各布综合征或朊病毒病（疯狗病）、弗里德里希共济失调、皮克氏病、巴森-科恩茨韦格综合征、雷夫索姆病、视网膜变性、克鲁兹费尔特-雅各布综合征或朊病毒病（疯牛病）、路易体痴呆、精神分裂症、副肿瘤性小脑变性以及中风引起的神经退行性疾病。本发明化合物可有效治疗乙酰胆碱传导神经元及其靶细胞受到影响的任何神经系统疾病。根据本发明的化合物可有效缓解和/或逆转神经退行性疾病的影响，防止进一步恶化和/或增强神经退行性疾病（尤其是阿尔茨海默氏症）患者的认知和记忆能力。
• NOVEL ANALOGS OF CHOLINE FOR NEUROPROTECTION AND COGNITIVE ENHANCEMENT IN NEURODEGENERATIVE DISORDERS
  申请人：BUCCAFUSCO Jerry J.

  公开号：US20100324064A1

  公开（公告）日：2010-12-23

  The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease, Alzheimer's disease and related disorders such as amyotrophic lateral sclerosis, spinal muscular atrophy, Friedrich's ataxia, Pick's disease, Bassen-Kornzweig syndrome, Refsom's disease, retinal degeneration, Cruetzfelt-Jacob syndrome or prion disease (mad cow disease), dementia with Lewy bodies, schizophrenia, paraneoplastic cerebellar degeneration and neurodegenerative conditions caused by stroke. The present compounds are effective to treat any neurological condition where acetylcholine transmission neurons and their target cells are affected. Compounds according to the present invention are effective to alleviate and/or reverse the effects of a neurodegenerative condition, prevent further deterioration and/or enhance cognition and memory in patients suffering from neurodegenerative disorders, especially Alzheimer's disease.
• US7786147B2
  申请人：——

  公开号：US7786147B2

  公开（公告）日：2010-08-31
• Secor, Henry V.; Seeman, Jeffrey I., Heterocycles, 1986, vol. 24, # 6, p. 1687 - 1698
  作者：Secor, Henry V.、Seeman, Jeffrey I.

  DOI：——

  日期：——