2-(3-氨基-4-羟基苯基)乙酸乙酯 | 86818-19-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(3-氨基-4-羟基苯基)乙酸乙酯
• 英文名称: Ethyl 3-amino-4-hydroxyphenylacetate
• 英文别名: 3-amino-4-oxy-phenyl-acetic acid-ethylester；Ethyl 2-(3-amino-4-hydroxyphenyl)acetate
• CAS: 86818-19-1
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: FTIJQCDTQOIKFU-UHFFFAOYSA-N

物化性质

• 熔点：
  102-105

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-氨基-4-羟基苯基)乙酸乙酯 在 硫酸 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 3-p-Chlorophenyl-2H-1,4-benzoxazine-6-acetic acid
  参考文献：
  名称：

  Shridhar, D. R.; Sastry, C. V. Reddy; Bansal, O. P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 3, p. 297 - 299

  摘要：

  DOI：

文献信息

• Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials
  申请人：——

  公开号：US20040198755A1

  公开（公告）日：2004-10-07

  Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.

  哌啶衍生物及其在哺乳动物，尤其是人类细菌感染治疗方法中的药物可接受衍生物。
• Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin
  申请人：——

  公开号：US20040236111A1

  公开（公告）日：2004-11-25

  A dithiazole compound or a salt thereof expressed by formula (I): 1 wherein R 1 is hydrogen atom, alkyl, etc.; R 2 is hydrogen atom, hydroxy, alkyl, aryl, arylalkoxy, arylalkyl, etc.; R 3 is one group of formulae (II), (III) and (IV): 2 This compound has an excellent inhibiting action on matrix metalloprotease (MMPs) activity, and is useful for pharmaceutical, cosmetic and skin external compositions.

  一种由式（I）表示的二噻唑化合物或其盐：其中，R1是氢原子，烷基等；R2是氢原子，羟基，烷基，芳基，芳基烷氧基，芳基烷基等；R3是式（II），（III）和（IV）的一种基团：该化合物对基质金属蛋白酶（MMPs）活性具有出色的抑制作用，并且在制药，化妆品和皮肤外用组合物中非常有用。
• 2-Aminophenol derivatives
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0081321A1

  公开（公告）日：1983-06-15

  2-AMINOPHENOL derivatives of the general formula: [wherein Z represents a straight alkylene or alkenylene group containing from 1 to 6 carbon atom(s), R1 represents a hydrogen atom, a halogen atom, a straight or branched chain alkyl group containing from 1 to 6 carbon atom(s), a straight or branched chain alkoxy group containing from 1 to 4 carbon atom(s) or a group represented by general formula: (wherein R4 represents a hydrogen atom or a straight or branched chain alkyl group containing from 1 to 6 carbon atom(s).), R2 represents a hydrogen atom, a straight or branched chain alkyl group containing from 1 to 4 carbon atom(s) or a group represented by a formula: R' is attached to the 6th or 4th position of the benzene ring: when R' is attached to the 6th position of the benzene ring, Z-COOR2 is attached to the 4th position of the benzene ring, and when R' is attached to the 4th position of the benzene ring, Z-COOR2 is attached to the 6th position of the benzene ring.] and pharmaceutically acceptable acid addition salts thereof, possess a strong inhibitory effect on 5-lipoxygenase specifically, or 5-lipoxygenase and cyclooxygenase at the same time, and therefore, are useful as treating and preventing agents for diseases which induced by leukotrienes, e.g. allergic tracheal and bronchial diseases or allergic lung diseases, allergic shocks or various allergic inflammations, and various inflammations induced by prostaglandins.

  通式如下的 2-氨基苯酚衍生物： [其中 Z 代表含 1 至 6 个碳原子的直链亚烷基或烯基，R1 代表氢原子、卤素原子、含 1 至 6 个碳原子的直链或支链烷基、含 1 至 4 个碳原子的直链或支链烷氧基或通式如下的基团： (其中 R4 代表氢原子或含有 1 至 6 个碳原子的直链或支链烷基），R2 代表氢原子、含有 1 至 4 个碳原子的直链或支链烷基或由通式表示的基团： R'连接到苯环的第6位或第4位：当R'连接到苯环的第6位时，Z-COOR2连接到苯环的第4位；当R'连接到苯环的第4位时，Z-COOR2连接到苯环的第6位]。 本品及其药学上可接受的酸加成盐对特异性 5-脂氧合酶或同时对 5-脂氧合酶和环氧合酶有很强的抑制作用，因此可作为治疗和预防由白三烯诱发的疾病的药物，如过敏性气管和支气管疾病或过敏性肺部疾病、过敏性休克或各种过敏性炎症以及由前列腺素诱发的各种炎症。
• DITHIAZOLE COMPOUNDS, MATRIX METALLOPROTEASE INHIBITORS AND EXTERNAL PREPARATIONS FOR THE SKIN
  申请人：Shiseido Co., Ltd.

  公开号：EP1422224B1

  公开（公告）日：2007-12-19
• SHRIDHAR, D. R.;SASTRY, C. V. REDDY;BANSAL, O. P.;RAO, P. PULLA, INDIAN J. CHEM., 1983, 22, N 3, 297-299
  作者：SHRIDHAR, D. R.、SASTRY, C. V. REDDY、BANSAL, O. P.、RAO, P. PULLA

  DOI：——

  日期：——