4-benzyl-3-chlorophenol | 67601-25-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-benzyl-3-chlorophenol
• 英文别名: 4-benzyl-3-chloro-phenol；4-Benzyl-3-chlor-phenol
• CAS: 67601-25-6
• 化学式: C₁₃H₁₁ClO
• 分子量: 218.683
• InChiKey: ASUSQGASZMYBQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  C₁₃H₁₁ClO₂ 在 甲酸 、 C₁₈H₂₄ClIrN₃⁽¹⁺⁾*Cl^(1-) 作用下， 以 水 为溶剂， 以99 %的产率得到4-benzyl-3-chlorophenol
  参考文献：
  名称：

  通过铱催化的醇的位点特异性脱氧反应获得对烷基酚

  摘要：

  铱催化和苯酚引导的苄醇脱氧是制备 4-烷基苯酚的替代方案，具有催化剂负载量低（S / C高达 20,000，TOF 高达 12,400 h –1）、高功能兼容性和优异的现场性等特点-选择性。重点介绍了天麻提取物在类固醇后期修饰和克级全合成中的应用。从机理上讲，醌甲基化物的中间作用控制了位点选择性，氢化铱的形成作为限速步骤。

  DOI：

  10.1021/acs.joc.3c01294

文献信息

• Antimicrobial composition and tissue containing it
  申请人：Satisloh AG

  公开号：EP2850943A1

  公开（公告）日：2015-03-25

  The present invention relates to an antimicrobial and antifog composition comprising: (a) at least a non ionic surfactant comprising a hydrophilic unit and a hydrophobic unit, said hydrophilic unit containing poly(oxyalkylene) units responding to the [-(R1-O)z-]n with R1 represents linear or branched alkylene groups, such as propylene or ethylene and z is an integer equal or higher than 1, preferably ranging from 1 to 40, the number n of said poly(oxyalkylene) units being equal or higher than 3, and (b) at least an alcohol compound of low molecular weight equal or less than 500 g/mol, whererin the weight ratio R of the non ionic surfactant/alcohol compound is such that 2.5≤R≤200 and the content of the at least alcohol compound by weight, relative to the total weight of the antimicrobial composition is ranging from 0.01% to 5%. The present invention also relates to an aqueous solution comprising the above mentionned antimicrobial and antifog composition, and dry microfiber tissue and non woven wet tissue impregnated with said aqueous solution, and an opticle article comprising a main surface coated with a temporary antimicrobial film or coating obtained by wiping said main surface with one of the above tissues.

  本发明涉及一种抗菌防雾组合物，包括 (a) 至少一种非离子表面活性剂，包括一个亲水单元和一个疏水单元，所述亲水单 元含有响应于[-(R1-O)z-]n的聚氧亚烷基单元，其中R1代表直链或支链亚烷基，如 丙烯或乙烯，z为等于或大于1的整数，优选范围为1至40，所述聚氧亚烷基单元 的数目n等于或大于3，以及 (b) 至少一种分子量等于或小于 500 克/摩尔的低分子量醇化合物、 其中，非离子表面活性剂/醇类化合物的重量比 R 为 2.5≤R≤200，至少醇类化合物的重量比含量占抗菌剂组合物总重量的 0.01%至 5%。 本发明还涉及一种水溶液，该水溶液包括上述抗菌防雾组合物、浸渍了上述水溶液的干超细纤维纸巾和无纺湿纸巾，以及一种光学器件，该光学器件的主表面涂有临时抗菌膜或涂层，该抗菌膜或涂层是用上述纸巾之一擦拭主表面而获得的。
• DE824058
  申请人：——

  公开号：——

  公开（公告）日：——
• Identification, library synthesis and anti-vibriosis activity of 2-benzyl-4-chlorophenol from cultures of the marine bacterium Shewanella halifaxensis
  作者：Sarah L. Moore、Lucile Berthomier、Chriselle D. Braganza、Joanna K. MacKichan、Jason L. Ryan、Gabriel Visnovsky、Robert A. Keyzers

  DOI：10.1016/j.bmcl.2016.05.002

  日期：2016.7

  Summer Gut Syndrome (SGS) is caused by various Vibrio bacterial species and can have negative effects on aquaculture farms worldwide. In New Zealand, SGS is caused by Vibrio harveyii infecting King Salmon (Oncorhynchus tshawytscha). To find leads for the prevention of SGS, we screened the inhibitory effects of 16 strains of Shewanella upon V. harveyii growth in competitive solid phase cultures. The detailed investigation of Shewanella halifaxensis IRL548 revealed 2-benzyl-4-chlorophenol (1), a known, commercially available antibacterial agent, as the major bioactive component. Synthesis of a small library of congeners to confirm the natural product identity and to provide a structure-activity relationship for the observed activity was also completed. Compound 1 exhibits moderate activity against two pathogenic microorganisms. (C) 2016 Published by Elsevier Ltd.
• ALIEVA, (TURAEVA), M. K.;AXMEDOV, K. N.;ABDURASULEVA, A. R., DOKL. AN UZSSR, 1983, N 1, 32-33
  作者：ALIEVA, (TURAEVA), M. K.、AXMEDOV, K. N.、ABDURASULEVA, A. R.

  DOI：——

  日期：——
• ALIEVA, M. K.;AXMEDOV, K. N., ZH. ORGAN. XIMII, 1983, 19, N 10, 2131-2134
  作者：ALIEVA, M. K.、AXMEDOV, K. N.

  DOI：——

  日期：——