3-chlorophenyl 4-acetylphenyl ether | 1145-57-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chlorophenyl 4-acetylphenyl ether
• 英文别名: 4-(3'-chlorophenoxy)acetophenone；1-[4-(3-chloro-phenoxy)-phenyl]-ethanone；1-[4-(3-Chlor-phenoxy)-phenyl]-aethanon；4-(3'-chlorophenoxy)-acetophenone；4-<3-Chlor-phenoxy>-acetophenon；4'-(3-Chlorphenoxy)acetophenon；1-[4-(3-Chlorophenoxy)phenyl]ethanone
• CAS: 1145-57-9
• 化学式: C₁₄H₁₁ClO₂
• mdl: MFCD01627700
• 分子量: 246.693
• InChiKey: LLSIXNNZOJEFCK-UHFFFAOYSA-N

物化性质

• 沸点：
  170-172 °C(Press: 3.5 Torr)
• 密度：
  1.212±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-chlorophenyl 4-acetylphenyl ether 在 盐酸 、 sodium hydroxide 、 potassium permanganate 作用下， 生成 Methyl 4-(3-chlorophenoxy)benzoate
  参考文献：
  名称：

  BE612755

  摘要：

  公开号：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 copper(l) chloride 作用下， 生成 3-chlorophenyl 4-acetylphenyl ether
  参考文献：
  名称：

  Kimoto et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1954, vol. 74, p. 358

  摘要：

  DOI：

文献信息

• 4-PHENYL-1,3-THIAZOLES AND 4-PHENYL-1,3-OXAZOLES DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS
  申请人：Harnett Jeremiah

  公开号：US20110059970A1

  公开（公告）日：2011-03-10

  The present invention relates to new 4-phenyl-1,3-azole derivatives having the general formula (I) wherein R1, R2, R3, R4, X, A, B, and n are variable, in a racemic form, an enantiomeric form or any combinations thereof. These compounds exhibit affinity for cannabinoid receptors and may therefore be used as drugs to treat or prevent pathological states and diseases in which one or more of these receptors are involved. The invention also relates to pharmaceutical compositions containing said products and to the use thereof to prepare a drug.

  本发明涉及具有一般式(I)的新4-苯基-1,3-唑衍生物，其中R1、R2、R3、R4、X、A、B和n是可变的，在消旋形式、对映异构体形式或任何组合中。这些化合物对大麻素受体具有亲和力，因此可用作药物治疗或预防涉及其中一个或多个这些受体的病理状态和疾病。本发明还涉及含有所述产品的药物组合物以及利用它们制备药物的用途。
• Litvinenko, L. M.; Benndorf, V.; Popova, R. S., Journal of Organic Chemistry USSR (English Translation), 1983, vol. 19, # 4, p. 680 - 683
  作者：Litvinenko, L. M.、Benndorf, V.、Popova, R. S.、Popov, A. F.、Tormosin, I. I.

  DOI：——

  日期：——
• Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation
  作者：Michael J. Gorczynski、Rachel M. Leal、Susan L. Mooberry、John H. Bushweller、Milton L. Brown

  DOI：10.1016/j.bmc.2003.12.003

  日期：2004.3

  Several substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles were synthesized and evaluated for cytotoxic activity against estrogen-positive, estrogen-negative, and adriamycin-resistant human breast cancer cell lines. 4-[4'-(3,4-Dichlorophenoxy)-phenyl]-thiazol-2-yl ammonium iodide demonstrated potent activity against both estrogen-positive and negative breast cancer cell lines with low micromolar (muM) GI(50) values. In addition, we have identified several 2-aminothiazoles that demonstrated selective potency for the adriamycin-resistant and estrogen-negative breast cancer cell lines. The results suggest that these 2-aminothiazoles represent lead compounds for evaluation in animal models of breast cancer. (C) 2003 Elsevier Ltd. All rights reserved.
• BE639727
  申请人：——

  公开号：——

  公开（公告）日：——
• BE612755
  申请人：——

  公开号：——

  公开（公告）日：——