2-(3-硝基苯基)吡咯烷 | 852281-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 2-(3-硝基苯基)吡咯烷
• 英文名称: 2-(3-nitrophenyl)pyrrolidine
• CAS: 852281-23-3
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: GWKHUTICOQRERL-UHFFFAOYSA-N

物化性质

• 沸点：
  309℃
• 密度：
  1.195
• 闪点：
  141℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-(3-Nitro-phenyl)-3,4-dihydro-2H-pyrrole 在 sodium tetrahydroborate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成 2-(3-硝基苯基)吡咯烷
  参考文献：
  名称：

  Hammett Correlation of Nornicotine Analogues in the Aqueous Aldol Reaction:  Implications for Green Organocatalysis

  摘要：

  A series of meta- and para-substituted 2-arylpyrrolidines were synthesized and examined for their ability to catalyze an aqueous aldol reaction under buffered conditions. Kinetic analysis of arylpyrrolidine-catalyzed reactions displayed a linear Hammett correlation with rho = 1.14 (R-2 = 0.996), indicating that the reaction is accelerated by electron-withdrawing aryl rings. These results show promise for the development of a synthetically viable aqueous organo-catalyst.

  DOI：

  10.1021/jo050161r

文献信息

• Hammett Correlation of Nornicotine Analogues in the Aqueous Aldol Reaction:  Implications for Green Organocatalysis
  作者：Claude J. Rogers、Tobin J. Dickerson、Andrew P. Brogan、Kim D. Janda

  DOI：10.1021/jo050161r

  日期：2005.4.1

  A series of meta- and para-substituted 2-arylpyrrolidines were synthesized and examined for their ability to catalyze an aqueous aldol reaction under buffered conditions. Kinetic analysis of arylpyrrolidine-catalyzed reactions displayed a linear Hammett correlation with rho = 1.14 (R-2 = 0.996), indicating that the reaction is accelerated by electron-withdrawing aryl rings. These results show promise for the development of a synthetically viable aqueous organo-catalyst.