1,4-bis(isopropylthio)butane | 115412-51-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,4-bis(isopropylthio)butane
• 英文别名: 1,4-Bis(propan-2-ylsulfanyl)butane
• CAS: 115412-51-6
• 化学式: C₁₀H₂₂S₂
• 分子量: 206.417
• InChiKey: BZUKYDCMZVMCTR-UHFFFAOYSA-N

物化性质

• 沸点：
  78-81 °C(Press: 1 Torr)
• 密度：
  0.928±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1Z,5Z)-cycloocta-1,5-diene,iridium,tetrafluoroborate 、 1,4-bis(isopropylthio)butane 以 二氯甲烷 为溶剂， 以82%的产率得到[Ir(1,5-cyclooctadiene)(1,4-bis(isopropylthio)butane)]BF4
  参考文献：
  名称：

  Rh(I) and Ir(I) dithioether complexes and their application in the hydrogenation of olefins

  摘要：

  Mononuclear complexes [M(cod)(RS(CH2)(n)SR)]BF4 (M = Rh, Ir; n = 2-4)) were synthesized and characterized. The crystal structure of [Rh(cod){(CH3)(2)CHS(CH2)(4)SCH(CH3)(2)}]BF4 was determined by X-ray diffraction. The iridium complexes are catalytically active precursors in the hydrogenation of olefins. The effect of the length of the backbone between the two sulfur atoms and the group R bonded to sulfur was studied in the hydrogenation of itaconic acid and 1-hexene. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(01)00623-5
• 作为产物：
  描述：

  1,4-二氯丁烷 、 2-丙烷硫醇钠 生成 1,4-bis(isopropylthio)butane
  参考文献：
  名称：

  ANKLAM, ELKE, SYNTHESIS,(1987) N 9, 841-843

  摘要：

  DOI：

文献信息

• Synthese von α-Halogen-ω-alkylthio-alkanen und α,ω-Bisalkylthio-alkanen
  作者：Elke Anklam

  DOI：10.1055/s-1987-28097

  日期：——

  Synthesis of α-Halogeno-ω-alkylthioalkanes and α,ω-Bisalkylthioalkanes The reaction of α,ω-dihalogenated alkanes [X(CH2)nX,,n = 3 - 10]with alkylthiolates affords α-halogeno-ω-alkylthioalkanes 1 as well as α,ω-bisalkylthioalkanes 2. Products 1 (40 examples) and 2 (22 examples) are easily isolated in good yields by flash chromatography.

  α-卤代-β-烷硫基烷和α,β-双烷硫基烷的合成 α,β-二卤代烷[X(CH2)nX，n = 3 - 10]与烷硫醇盐反应生成α-卤代-β-烷硫基烷1以及α,β-双烷硫基烷2。产品1（40个例子）和2（22个例子）通过闪式色谱法容易地分离，并获得良好的收率。
• SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS
  申请人：Old David W.

  公开号：US20100093729A1

  公开（公告）日：2010-04-15

  A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related to these compounds are also disclosed.

  本文揭示了一种包含或其药用可接受的盐、前药或代谢产物的化合物。Y、A和B如本文所述。还公开了与这些化合物相关的方法、组合物和药物。
• SUBSTITUTED ARYLCYCLOPENTENES AS THERAPEUTIC AGENTS
  申请人：Old David W.

  公开号：US20090270385A1

  公开（公告）日：2009-10-29

  Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein G, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are also disclosed.

  本申请揭示了包含或其药用可接受的盐或其前药的化合物，其中G、B、Y和A如所述。还公开了与之相关的方法、组合物和药物。
• SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY
  申请人：Burk Robert M.

  公开号：US20090197962A1

  公开（公告）日：2009-08-06

  Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.

  本文揭示了治疗化合物、组合物、方法和相关药物。
• THERAPEUTIC SUBSTITUTED HYDANTOINS AND RELATED COMPOUNDS
  申请人：Old David W.

  公开号：US20080058397A1

  公开（公告）日：2008-03-06

  A compound having a structure is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

  本文披露了一种具有结构的化合物。同时还披露了与其相关的治疗方法、组合物和药物。