2-(4'-氨基苄基)咪唑啉 | 13623-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(4'-氨基苄基)咪唑啉
• 英文名称: 4-(4,5-dihydro-1H-imidazol-2-ylmethyl)-aniline
• 英文别名: 4-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-anilin；4-(4,5-dihydro-1H-imidazol-2-ylmethyl)-phenylamine；2-(4'-Aminobenzyl)imidazoline；4-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
• CAS: 13623-47-7
• 化学式: C₁₀H₁₃N₃
• 分子量: 175.233
• InChiKey: NTVVAXXCLZJWPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  2-(4'-氨基苄基)咪唑啉 、 硫光气 以43%的产率得到
  参考文献：
  名称：

  Slavica Meri, Lei Longping, Patil Popat N., Kerezy Alex, Feller Dennis R.+, J. Med. Chem, 37 (1994) N 12, S 1874-1881

  摘要：

  DOI：
• 作为产物：
  描述：

  对硝基苯乙腈 在 盐酸 、 氢气 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 1.33h， 生成 2-(4'-氨基苄基)咪唑啉
  参考文献：
  名称：

  Benzylimidazolines as h5-HT_1B/1D Serotonin Receptor Ligands: A Structure−Affinity Investigation

  摘要：

  Benzylimidazolines may represent a class of 5-HT1D ligands that has yet to be exploited. On the basis of a previous report that the 2-(substituted-benzyl)imidazoline alpha-adrenergic agonist oxymetazoline (8) binds with high affinity at calf brain 5-HT1D receptors, we explored the structure-affinity relationships of a series of related derivatives. Each of the aromatic substituents was removed and then reinstated in a systematic manner to determine the influence of the individual substituents on binding. It was found that all of the aromatic substituents of 8 act in concert to impart high affinity. However, although the 3-hydroxy group could be removed without significantly reducing affinity for h5-HT1D (i.e., human 5-HT1D alpha) receptors, this modification reduced h5-HT1B (i.e., human 5-HT1D beta) receptor affinity by nearly 50-fold. The 2,6-dimethyl groups also contribute to binding but seem to play a greater role for h5-HT1B binding than h5-HT1D binding.With the appropriate structural modifications, several compounds were identified that display 20- to >100-fold selectivity for h5-HT1D versus h5-HT1B receptors. Preliminary functional data suggest that these compounds behave as agonists. Given that 5-HT1D agonists are currently being explored for their antimigraine action and that activation of h5-HT1B receptors might be associated with cardiovascular side effects, h5-HT1D-selective agents may offer a new lead for the development of therapeutically efficacious agents.

  DOI：

  10.1021/jm970513p

文献信息

• Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
  申请人：Galley Guido

  公开号：US20070197621A1

  公开（公告）日：2007-08-23

  The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R 1 , R 2 , A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.

  本发明涉及一种治疗抑郁症、焦虑症、双相情感障碍、注意力缺陷多动障碍、压力相关障碍、精神分裂症等精神障碍、帕金森病等神经系统疾病、阿尔茨海默病等神经退行性疾病、癫痫、偏头痛、高血压、物质滥用、进食障碍、糖尿病、糖尿病并发症、肥胖症、血脂异常、能量消耗和吸收障碍、体温稳态障碍、睡眠和昼夜节律障碍以及心血管疾病的方法，包括向个体施用化合物I的治疗有效量，其中R、R1、R2、A和n如规范中所定义，以及其药用活性盐。该发明还涉及化合物I的新颖化合物、含有它们的药物组合物以及它们的制备方法。
• Selected substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
  申请人：Garofalo W. Albert

  公开号：US20050032868A1

  公开（公告）日：2005-02-10

  Disclosed are compounds that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  本发明涉及一种用于治疗哺乳动物中由于缓激肽B1受体介导的疾病或缓解与疾病状态相关的不良症状的缓激肽B1受体拮抗剂化合物。其中某些化合物表现出增强的效力，并且预计还会表现出增强的作用持续时间。
• 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (phenyl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
  申请人：Garofalo W. Albert

  公开号：US20070123531A1

  公开（公告）日：2007-05-31

  Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  本发明涉及一种可以用于治疗哺乳动物中由于Bradykinin B1受体介导的疾病或缓解与疾病状态相关的不良症状的化合物，这些化合物是Bradykinin B1受体拮抗剂。其中某些化合物表现出增强的效力，并且预计还将表现出增加的作用持续时间。
• Polyvinyl chloride plastisol composition
  申请人：ASAHI DENKA KOGYO KABUSHIKI KAISHA

  公开号：EP0331507A1

  公开（公告）日：1989-09-06

  The present invention provides a polyvinyl chloride plastisol composition characterized by containing a specified epoxy resin, a blocked isocyanate and, if necessary, a latent curing agent for an epoxy resin as tackifiers. This plastisol composition is excellent in storage stability and can strongly adhere to various metals and various undercoats of metals (such as electro-deposit) by baking even at a relatively low temperature to give a coating which is free from blowing and exhibits excellent adhesion after the immersion in hot water or the heating. Therefore, the composition is useful as a body sealer or undercoat for an automotive body.

  本发明提供了一种聚氯乙烯增塑溶胶组合物，其特点是含有特定的环氧树脂、封端异氰酸酯，必要时还含有环氧树脂的潜在固化剂作为增粘剂。这种增塑溶胶组合物具有出色的储存稳定性，即使在相对较低的温度下烘烤，也能牢固地附着在各种金属和金属的各种底涂层（如电沉积层）上，使涂层在热水中浸泡或加热后不起泡，并表现出出色的附着力。因此，该组合物可用作汽车车身的密封剂或底漆。
• 96. Amidines. Part VI. Preparation of 2-substituted 4 : 5-dihydroglyoxalines and ring homologues from cyanides and alkylenediamines
  作者：P. Oxley、W. F. Short

  DOI：10.1039/jr9470000497

  日期：——