4-(2-(diethylamino)ethylsulfanyl)aniline | 40179-35-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-(2-(diethylamino)ethylsulfanyl)aniline
• 英文别名: (4-Amino-phenyl)-(2-diethylamino-ethyl)-sulfid；<4-Amino-phenyl>-<2-diethylamino-ethyl>-sulfid；4-(2-Diaethylamino-aethylmercapto)-anilin；4-[[2-(diethylamino)ethyl]thio]benzenamine；4-(2-diethylamino-ethylsulfanyl)-phenylamine；4-[2-(diethylamino)ethylsulfanyl]aniline
• CAS: 40179-35-9
• 化学式: C₁₂H₂₀N₂S
• 分子量: 224.37
• InChiKey: LONHIKNRVFLWFP-UHFFFAOYSA-N

物化性质

• 熔点：
  57 °C
• 沸点：
  140 °C(Press: 0.5 Torr)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-(diethylamino)ethylsulfanyl)aniline 在 盐酸 、 potassium carbonate 作用下， 以 乙二醇甲醚 为溶剂， 反应 25.25h， 生成 N-[4-[2-(diethylamino)ethylsulfanyl]phenyl]-4-pyridin-4-ylpyrimidin-2-amine
  参考文献：
  名称：

  Preparation of substituted N-phenyl-4-aryl-2-pyrimidinamines as mediator release inhibitors

  摘要：

  The role of immunologically released mediators, such as histamine, leukotrienes, and platelet-activating factor, is well-established for asthma and other allergic disorders. Developing therapeutic agents which would block mediator release from mast cells and other relevant cell types would provide a rational approach to asthma therapy. Using human basophil as a screen, a series of 4-aryl-2-(phenylamino)pyrimidines was found which inhibited mediator release. These compounds were prepared by condensing acetyl heterocycles with dimethylformamide dimethyl acetal to form enaminones which are cyclized with aryl guanidines to give pyrimidines. After examining a large number of analogs, N-[3-(1H-imidazol-1-yl)phenyl]-4-(2-pyridinyl)-2-pyrimidinamine (1-27) was chosen for toxicological evaluation.

  DOI：

  10.1021/jm00071a002
• 作为产物：
  描述：

  diethyl-[2-(4-nitro-phenylsulfanyl)-ethyl]-amine 在 盐酸 、 tin 作用下， 生成 4-(2-(diethylamino)ethylsulfanyl)aniline
  参考文献：
  名称：

  Kurihara et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 1541,1544

  摘要：

  DOI：

文献信息

• Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as
  申请人：Schering A.G.

  公开号：US04906634A1

  公开（公告）日：1990-03-06

  Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents, especially as antiarrhythmic agents are described. Pharmaceutical formulations containing such compounds are also discussed.

  描述了新型N-[4-(氨基取代)苯基]甲磺酰胺类化合物及其作为心血管药物的用途，特别是作为抗心律失常药物的用途。还讨论了含有这类化合物的药物配方。
• [EN] PYRIMIDINONES AS MELANIN CONCENTRATING HORMONE RECEPTOR 1<br/>[FR] PYRIMIDINONES EN TANT QUE RECEPTEUR 1 DE L'HORMONE DE CONCENTRATION DE LA MELANINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2003033476A1

  公开（公告）日：2003-04-24

  A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided

  本发明提供了化合物(Ia)的配方，包括其药物可接受的盐或溶剂，制备过程和哺乳动物的给药方法。
• Pyrimidinones as melanin concentrating hormone receptor 1
  申请人：——

  公开号：US20040220404A1

  公开（公告）日：2004-11-04

  A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided 1

  提供了一种化合物(Ia)的配方，包括其药用可接受的盐或溶剂，制备过程以及对哺乳动物的给药方法。
• DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  申请人：Molteni Valentina

  公开号：US20090012094A1

  公开（公告）日：2009-01-08

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文介绍了一种包含二芳胺结构特征的化合物。还介绍了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的制药组合物和药物。本文还介绍了使用这种化合物、制药组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors
  申请人：Molteni Valentina

  公开号：US20070149538A1

  公开（公告）日：2007-06-28

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文描述了包含二芳胺结构特征的化合物。还描述了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的药物组合物和药物。本文还描述了使用这种化合物、药物组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。