2-amino-4-(4-fluorophenyl)-6-(perfluorophenylthio)pyridine-3,5-dicarbonitrile | 1350429-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-4-(4-fluorophenyl)-6-(perfluorophenylthio)pyridine-3,5-dicarbonitrile
• 英文别名: 2-Amino-4-(4-fluorophenyl)-6-(2,3,4,5,6-pentafluorophenyl)sulfanylpyridine-3,5-dicarbonitrile；2-amino-4-(4-fluorophenyl)-6-(2,3,4,5,6-pentafluorophenyl)sulfanylpyridine-3,5-dicarbonitrile
• CAS: 1350429-63-8
• 化学式: C₁₉H₆F₆N₄S
• 分子量: 436.34
• InChiKey: ADXRQSLMIDMOCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  五氟苯硫酚 、 对氟苯甲醛 、 丙二腈 在 zirconyl chloride octahydrate 、 sodium amide 作用下， 反应 0.08h， 以95%的产率得到2-amino-4-(4-fluorophenyl)-6-(perfluorophenylthio)pyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  Ultrasound-promoted synthesis of 2-amino-6-(arylthio)-4-arylpyridine-3,5-dicarbonitriles using ZrOCl2·8H2O/NaNH2 as the catalyst in the ionic liquid [bmim]BF4 at room temperature

  摘要：

  We herein present an efficient and environmentally benign protocol for the synthesis of 2-amino-6-(arylthio)-4-arylpyridine-3,5-dicarbonitrile derivatives via the three-component condensation of a variety of aldehydes, arylthiols, and malononitrile catalyzed by ZrOCl2 center dot 8H(2)O/NaNH2 (20 mol %) in the ionic liquid [bmim]BF4 under ultrasound irradiation at room temperature. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.031

文献信息

• Ultrasound-promoted synthesis of 2-amino-6-(arylthio)-4-arylpyridine-3,5-dicarbonitriles using ZrOCl2·8H2O/NaNH2 as the catalyst in the ionic liquid [bmim]BF4 at room temperature
  作者：Mohammad Reza Poor Heravi、Farnazalsadat Fakhr

  DOI：10.1016/j.tetlet.2011.10.031

  日期：2011.12

  We herein present an efficient and environmentally benign protocol for the synthesis of 2-amino-6-(arylthio)-4-arylpyridine-3,5-dicarbonitrile derivatives via the three-component condensation of a variety of aldehydes, arylthiols, and malononitrile catalyzed by ZrOCl2 center dot 8H(2)O/NaNH2 (20 mol %) in the ionic liquid [bmim]BF4 under ultrasound irradiation at room temperature. (C) 2011 Elsevier Ltd. All rights reserved.