4-methoxy-N-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide | 92255-51-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-N-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide
• 英文别名: 1-<4-Methoxy-benzamino>-2,5-dimethyl-pyrrol；N-(2,5-dimethyl-pyrrol-1-yl)-4-methoxy-benzamide；N-(2,5-dimethylpyrrol-1-yl)-4-methoxybenzamide
• CAS: 92255-51-1
• 化学式: C₁₄H₁₆N₂O₂
• 分子量: 244.293
• InChiKey: AYYZGYMSHYHIOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  43.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对甲氧基苯甲酰肼 、 2,5-己二酮 在 糖精 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以92%的产率得到4-methoxy-N-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide
  参考文献：
  名称：

  A facile synthesis of N-substituted 2,5-dimethylpyrroles with saccharin as a green catalyst

  摘要：

  The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal-Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.

  DOI：

  10.1007/s10593-015-1701-x

文献信息

• A facile synthesis of N-substituted 2,5-dimethylpyrroles with saccharin as a green catalyst
  作者：Namratha Bhandari、Santosh L. Gaonkar

  DOI：10.1007/s10593-015-1701-x

  日期：2015.4

  The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal-Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.