2-amino-4'-chloro-5-chlorobenzophenone | 136266-81-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-4'-chloro-5-chlorobenzophenone
• 英文别名: (2-amino-5-chloro-phenyl)-(4-chloro-phenyl)-methanone；(2-amino-5-chlorophenyl)(4-chlorophenyl)methanone；2-amino-5-chloro-4'-chloro-benzophenone；2-Amino-5,4'-dichlor-benzophenon；5.4'-Dichlor-2-amino-benzophenon；(2-amino-5-chlorophenyl)-(4-chlorophenyl)methanone
• CAS: 136266-81-4
• 化学式: C₁₃H₉Cl₂NO
• 分子量: 266.127
• InChiKey: JBKFVAVNIDDFFD-UHFFFAOYSA-N

物化性质

• 沸点：
  453.6±45.0 °C(Predicted)
• 密度：
  1.373±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-4'-chloro-5-chlorobenzophenone 在 氢氧化钾 、 sodium tetrahydroborate 作用下， 以 乙醇 、 水 为溶剂， 生成 6-chloro-4-(4-chloro-phenyl)-1,4-dihydro-benzo[d][1,3]thiazine-2-thione
  参考文献：
  名称：

  Lednicer,D.; Emmert,D.E., Journal of Heterocyclic Chemistry, 1971, vol. 8, p. 903 - 910

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氯靛红酸酐 在 正丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 为溶剂， 反应 2.17h， 生成 2-amino-4'-chloro-5-chlorobenzophenone
  参考文献：
  名称：

  Structure–Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Containing Class of GluN2C/GluN2D Selective Antagonists

  摘要：

  Here we describe the synthesis and structure-activity relationship for a class of pyrazoline-containing dihydroquinolone negative allosteric modulators of the NMDA receptor that show strong subunit selectivity for GluN2C- and GluN2D-containing receptors over GluN2A- and GluN2B-containing receptors. Several members of this class inhibit NMDA receptor responses in the nanomolar range and are more than 50-fold selective over GluN1/GluN2A and GluN1/GluN2B NMDA receptors, as well as AMPA, kainate, GABA, glycine, nicotinic, serotonin, and purinergic receptors. Analysis of the purified enantiomers of one of the more potent and selective compounds shows that the S-enantiomer is both more potent and more selective than the R-enantiomer. The S-enantiomer had an IC50 of 0.17-0.22 mu M at GluN2D- and GluN2C-containing receptors, respectively, and showed over 70-fold selectivity over other NMDA receptor subunits. The subunit selectivity of this class of compounds should be useful in defining the role of GluN2C- and GluN2D-containing receptors in specific brain circuits in both physiological and pathophysiological conditions.

  DOI：

  10.1021/jm400652r

文献信息

• Design, synthesis and evaluation of aminobenzophenone derivatives containing nitrogen mustard moiety as potential central nervous system antitumor agent
  作者：Rajesh K. Singh、D. N. Prasad、T. R. Bhardwaj

  DOI：10.1007/s00044-013-0582-8

  日期：2013.12

  A series of novel substituted aminobenzophenone derivatives containing nitrogen mustard moiety (5a–f) were synthesized and characterized on the basis of their IR, 1H NMR, 13C NMR, CHN, and mass spectral data. All the compounds when evaluated for chemical 4-(4-nitrobenzyl) pyridine alkylating activity proved to be active alkylating agents. All the synthesized compounds were subjected to physicochemical

  合成了一系列含有氮芥子部分（5a - f）的新型取代氨基二苯甲酮衍生物，并根据其IR，1 H NMR，13 C NMR，CHN和质谱数据进行了表征。当评估4-（4-硝基苄基）吡啶烷基化化学活性时，所有化合物均证明是活性烷基化剂。通过计算，在线软件和QikProp 3.2对所有合成的化合物进行中枢神经系统（CNS）活动所需的理化参数测定。日志P值和分析的其他计算机模拟ADME理化指标位于良好BBB渗透所需的范围之间。对人癌细胞系的体外抗增殖活性。研究了549（肺），COLO 205（结肠），U 87（胶质母细胞瘤）和IMR-32（神经母细胞瘤）。大多数测试化合物显示出有效的抗肿瘤活性，尤其是化合物（5f）显示出最高的抗CNS癌细胞活性，与苯丁酸氮芥和多西紫杉醇相当。初步的构效关系（SAR）表明，5-氯氨基二苯甲酮-芥末系列（5a-c）比5-硝基氨基二苯甲酮-芥末系列（5d-f）表现出更好的抗肿瘤活性。
• Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof
  申请人：——

  公开号：US20040058977A1

  公开（公告）日：2004-03-25

  The present invention relates to sulfonyl-containing 2,3-diarylindole, especially to new compounds of general Formula, to a preparation method for their preparation, to pharmaceutical compositions containing said compound, and to the medical use thereof in the treatment of diseases relating to the inhibition of cyclooxygenase-2 (COX-2).

  本发明涉及含砜基的2,3-二芳基吲哚，特别涉及一般式的新化合物，其制备方法，含有该化合物的药物组合物，以及在治疗与环氧合酶-2（COX-2）抑制有关的疾病中的医疗用途。
• Synthesis and Biological Evaluation of 4-Phenylquinazoline-2-carboxamides Designed as a Novel Class of Potent Ligands of the Translocator Protein
  作者：Sabrina Castellano、Sabrina Taliani、Ciro Milite、Isabella Pugliesi、Eleonora Da Pozzo、Elisa Rizzetto、Sara Bendinelli、Barbara Costa、Sandro Cosconati、Giovanni Greco、Ettore Novellino、Gianluca Sbardella、Giorgio Stefancich、Claudia Martini、Federico Da Settimo

  DOI：10.1021/jm201703k

  日期：2012.5.10

  A series of novel 4-phenylquinazoline-2-carboxamides (1–58) were designed as aza-isosters of PK11195, the well-known 18 kDa translocator protein (TSPO) reference ligand, and synthesized by means of a very simple and efficient procedure. A number of these derivatives bind to the TSPO with Ki values in the nanomolar/subnanomolar range, show selectivity toward the central benzodiazepine receptor (BzR)

  一系列新的4-苯基喹唑啉-2-羧酰胺（1 - 58）被设计为PK11195，公知的18 kDa的转运蛋白（TSPO）参考配体，的氮杂等排并合成由一个非常简单和有效的程序的装置。这些衍生物中的许多与TSPO结合的K i值在纳摩尔/亚纳摩尔范围内，对中央苯并二氮杂receptor受体（BzR）表现出选择性，并显示出结构亲和力关系，与先前公布的配体-TSPO相互作用的药效团/拓扑模型一致。
• Synthesis and spectral properties of 2-[(o- and p-substituted)aminophenyl] -3<i>H</i>-5-[(o- and<i>p</i>-substituted)phenyl]-7-chloro-1,4-benzodiazepines
  作者：Eduardo Cortés Cortés、Raúl Salazar Franco、Olivia García Mellado

  DOI：10.1002/jhet.5570380320

  日期：2001.5

  series of twelve new 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines, which have possible pharmacological properties has been obtained. The synthesis was carried out following six steps. The structure of all products was corroborated by ir, 1H nmr, 13C nmr and ms. In addition for the compound 2-(o-chloroaminophenyl)-3H-5-(o-fluorophenyl)-7-chloro-1

  一系列12新2 - [（ø -和p -取代的）氨基苯基] -3- ħ -5 - [（ø -和p -取代的）苯基] -7-氯-1,4-苯并二氮杂类，其具有可能的药理学属性已获得。合成按照六个步骤进行。ir，1 H nmr，13 C nmr和ms证实了所有产物的结构。另外，对于化合物2-（邻氯氨基苯基）-3 H -5-（邻氟苯基）-7-氯-1,4-苯并二氮杂pine7，通过X射线衍射确认了其结构。
• Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogs
  作者：David A. Walsh、H. Wayne Moran、Dwight A. Shamblee、Ibrahim M. Uwaydah、William J. Welstead、Lawrence F. Sancilio、Warren N. Dannenburg

  DOI：10.1021/jm00377a001

  日期：1984.11

  A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 157 (4'-chloro), 158 (4'-bromo), and 182 (5-chloro, 4'-bromo) were more potent than indomethacin in these assays.

  已经合成了一系列2-氨基-3-苯甲酰基苯基乙酸（氨苯乙酸）的取代衍生物，并评估了它们的抗炎，止痛和环加氧酶活性。在这些测定中，包括157（4'-氯），158（4'-溴）和182（5-氯，4'-溴）的几种衍生物比消炎痛更有效。