3,9-Bis(2-hydroxyethyl)-6-oxa-3,9-diaza-1,11-undecanediol | 55468-09-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,9-Bis(2-hydroxyethyl)-6-oxa-3,9-diaza-1,11-undecanediol
• 英文别名: ditriethanolamine；2-[2-[2-[Bis(2-hydroxyethyl)amino]ethoxy]ethyl-(2-hydroxyethyl)amino]ethanol
• CAS: 55468-09-2
• 化学式: C₁₂H₂₈N₂O₅
• 分子量: 280.365
• InChiKey: LCKPHCCJABIHJQ-UHFFFAOYSA-N

物化性质

• 沸点：
  468.2±40.0 °C(Predicted)
• 密度：
  1.180±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  96.6
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3,9-Bis(2-hydroxyethyl)-6-oxa-3,9-diaza-1,11-undecanediol 在 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 60.0~70.0 ℃ 、5.07 MPa 条件下， 反应 13.0h， 生成
  参考文献：
  名称：

  一锅交叉偶联反应中的树枝状双-和四-亚氨基二乙酸-硼酸酯络合物

  摘要：

  亚氨基二乙酸是通用的金属螯合配体。我们在本文中进行了在分支核心部分的外围官能化的树突状双-和四-亚氨基二乙酸的研究。树枝状亚氨基二乙酸是通过选择的从支链核上散发出的醇和胺反应性位点的O-和N-烷基化反应合成的。为了鉴定这种树突状亚氨基二乙酸的反应性，进行了与芳基硼酸酯的螯合。水溶液下水解的评估。基本条件表明，树枝状硼酸盐比单体硼酸盐水解得慢得多。利用树突状硼酸盐的较慢水解，以进行竞争性CC键形成的Suzuki-Miyaura交叉偶联反应。使用单体的和树枝状的硼酸酯进行三芳基化合物的合成。随后通过一锅中选择的硼酸，单体硼酸酯，树枝状硼酸酯和芳基溴化物的连续反应，进行重复的多个芳基-芳基键形成，从而制备四芳基。研究表明，为了进行多个连续的芳基-芳基键形成，较慢的树突状硼酸酯的水解是有价值的。

  DOI：

  10.1016/j.jorganchem.2016.06.030
• 作为产物：
  描述：

  2,2'-oxybis(N,N-bis(2-hydroxyethyl)acetamide) 在 lithium aluminium tetrahydride 作用下， 以 1,4-二氧六环 为溶剂， 反应 48.0h， 生成 3,9-Bis(2-hydroxyethyl)-6-oxa-3,9-diaza-1,11-undecanediol
  参考文献：
  名称：

  Synthesis and complexation properties of new unsymmetrical cryptands

  摘要：

  Twelve novel unsymmetrical cryptands (1-12) containing various units (methylene, 2-methylenylpropylene, pyridine-2,6-diyldimethylene, o- and m-xylylene) each in two bridges have been synthesized by a one-step cyclization procedure. These cryptands were obtained by treating tetraalcohols 15-17, obtained from diethanolamine and diglycolyl dichloride followed by reduction or from diethanolamine and the appropriate oligoethylene glycol dichloride or ditosylate, with methylene chloride, 3-chloro-2-(chloromethyl)-l-propene, alpha,alpha'-dibromo-o-xylene, alpha,alpha'-dibromo-m-xylene, and 2,6-pyridinediyldimethyl ditosylate. Cryptancls 7 and 11, containing two acetal functions, were obtained in yields of 59 and 40%, respectively. Bis(2-methylenepropylene)-bridged cryptand 4 was independently synthesized by another method. Complexation properties of nearly all of these cryptands with the alkali metal cations were studied by an NMR technique. Some of the results were verified by a calorimetric titration technique. Cryptands 5 and 9, containing a 2,6-pyridinediyldimethylene unit in two bridges, and 11, containing a methylene unit in two bridges, showed high selectivity for potassium over sodium ions by factors ranging from 40 to 200. Bisacetal-containing cryptand 7 exhibited high selectivity for sodium over potassium ions with a selectivity factor of over 1000.

  DOI：

  10.1021/jo00049a013

文献信息

• In-plane modulated smectic à vs smectic ‘A’ lamellar structures in poly(ethyl or propyl ether imine) dendrimers
  作者：Prabhat Kumar、D.S. Shankar Rao、S. Krishna Prasad、N. Jayaraman

  DOI：10.1016/j.polymer.2016.01.043

  日期：2016.3

  A pair of first and second generation poly(alkyl ether imine) dendrimers is prepared, having covalently attached cholesteryl moieties at their peripheries. The pairs in each generation differ in the alkyl-linker which constitute the dendritic core moieties, even when the number of cholesteryl moieties remains uniform in each pair. The dendrimer pairs are two first and second generation poly(ethyl ether

  制备一对第一和第二代聚（烷基醚亚胺）树状聚合物，它们在其外围具有共价连接的胆固醇基部分。即使当每一对中的胆固醇基部分的数目保持均匀时，每一代中的对在构成树突状核心部分的烷基连接基上也不同。树枝状大分子对是两个第一和第二代聚（乙基亚胺）和聚（丙基）醚亚胺）树状大分子，分别在每对外围用4和8个胆固醇酯改性。树枝状聚合物对表现出不同的热致中间相性质。显微，热和X射线衍射研究表明，第一代乙基，第一代和第二代丙基接头树状聚合物的层状中间相。而第二代乙基接头树状聚合物表现出具有叠加的面内调制的层状结构，其长度对应于矩形柱的宽度。研究了具有不同接头的树枝状聚合物核心部分在修饰中间相性质中的作用。
• Skin cosmetic composition
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0685229A1

  公开（公告）日：1995-12-06

  A preparation for external application to the skin which comprises disodium adenosine triphosphate and tranexamic acid for prevention of skin roughening and skin improvement. The preparation further contains ginseng extract.

  一种用于皮肤外用的制剂，由三磷酸腺苷二钠和氨甲环酸组成，用于防止皮肤粗糙和改善皮肤。该制剂还含有人参提取物。
• Skin-cosmetic composition
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：EP0754447A1

  公开（公告）日：1997-01-22

  Disclosed is a skin-food cosmetic composition containing, as the active ingredient, at least one compound of the formula (I): R1 represents an alkyl group having 1 to 10 carbon atoms; R2 represents an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, or a cycloalkyl cycloalkyl group having 3 to 7 carbon atoms; and X represents -O- or -NH-. This is useful for preventing the skin from being roughened, chapped or cracked, or from being aged.

  本发明公开了一种含有至少一种式(I)化合物作为活性成分的护肤化妆品组合物： R1 代表具有 1 至 10 个碳原子的烷基； R2 代表具有 1 至 10 个碳原子的烷基、具有 2 至 6 个碳原子的烯基或具有 3 至 7 个碳原子的环烷基；以及 X 代表 -O- 或 -NH-。这对于防止皮肤粗糙、皲裂或老化非常有用。
• AGENT FOR EXTERNAL APPLICATION TO THE SKIN
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP1894558A1

  公开（公告）日：2008-03-05

  The present invention has an object to provide an agent for suppressing melanin production and/or inhibiting elastase activity containing a plant extract as an effective substance with high safety and acceptable levels of stability and odor or sediment formation and an agent for external application to the skin comprising the above agent which has excellent effects in skin-whitening and skin-beautifying. The object is attained by providing an agent for external application to the skin containing indigo-plant extract.

  本发明的目的是提供一种抑制黑色素生成和/或抑制弹性蛋白酶活性的制剂，该制剂含有一种植物提取物作为有效物质，安全性高，稳定性和气味或沉淀物的形成水平可接受，并提供一种由上述制剂组成的皮肤外用制剂，该制剂在皮肤美白和皮肤美容方面具有极佳的效果。通过提供一种含有靛蓝植物提取物的皮肤外用制剂，可以达到上述目的。
• ANTI-AGING EXTERNAL SKIN PREPARATION
  申请人：Hayashibara Co., Ltd.

  公开号：EP3130332A1

  公开（公告）日：2017-02-15

  The present invention aims to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as age-related or senescent wrinkles, fine wrinkles, saggings, spots, etc., as well as maintaining or enhancing the skin barrier functions. The object is solved by providing an external dermal agent for anti-ageing, which contains as an effective ingredient(s) one or more members selected from the group consisting of adenosine N1-oxide 5'-phosphate, analogues thereof, and their salts.

  本发明旨在提供一种用于抗衰老的外用皮肤组合物，该组合物可预防或改善明显的皮肤问题，如与年龄有关的或衰老性皱纹、细小皱纹、疤痕、斑点等，以及保持或增强皮肤屏障功能。本发明的目的是提供一种用于抗衰老的外用皮肤制剂，该制剂含有一种或多种有效成分，这些成分选自 5'-磷酸腺苷 N1-氧化物、其类似物及其盐组成的组。