2-(4-吗啉基)-吡啶-4-羧酸叔丁酯 | 295349-63-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(4-吗啉基)-吡啶-4-羧酸叔丁酯
• 英文名称: 2-(4-Morpholinyl)-pyridine-4-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 2-morpholin-4-ylpyridine-4-carboxylate
• CAS: 295349-63-2
• 化学式: C₁₄H₂₀N₂O₃
• 分子量: 264.32
• InChiKey: KTZSLYFETZWANR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Amide derivatives
  申请人：ASTRAZENECA AB

  公开号：US20030186966A1

  公开（公告）日：2003-10-02

  This invention concerns amide derivatives of Formula (I) wherein X is CH or N; Y is CH or N; m is 0-3; R 1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-3; R 2 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and (1-6C)alkoxycarbonyl; R 3 is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino, N-(1-6C)alkyl-arylamino and aryl-(1-6C)alkylamino; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

  本发明涉及式（I）的酰胺衍生物，其中X为CH或N; Y为CH或N; m为0-3; R1为羟基、卤素、三氟甲基、氰基、巯基、硝基、氨基、羧基和氨基甲酰基等基团; n为0-3; R2为羟基、卤素、三氟甲基、氰基、巯基、硝基、氨基、羧基和(1-6C)烷氧基甲酰基等基团; R3为氢、卤素、(1-6C)烷基或(1-6C)烷氧基; q为0-4; Q为芳基、芳氧基、芳基-(1-6C)烷氧基、芳基氨基、N-(1-6C)烷基芳基氨基和芳基-(1-6C)烷基氨基等基团; 或其药学上可接受的盐或体内可降解的酯; 以及制备它们的方法、含有它们的制药组合物以及它们在通过细胞因子介导的疾病或医疗状况的治疗中的应用。
• AMIDE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1163212A1

  公开（公告）日：2001-12-19
• US6548514B1
  申请人：——

  公开号：US6548514B1

  公开（公告）日：2003-04-15
• US6794380B2
  申请人：——

  公开号：US6794380B2

  公开（公告）日：2004-09-21
• [EN] AMIDE DERIVATIVES<br/>[FR] DERIVES AMIDES
  申请人：ASTRAZENECA AB

  公开号：WO2000055120A1

  公开（公告）日：2000-09-21

  This invention concerns amide derivatives of Formula (I) wherein X is CH or N; Y is CH or N; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-3; R2 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and (1-6C)alkoxycarbonyl; R3 is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino, N-(1-6C)alkyl-arylamino and aryl-(1-6C)alkylamino; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.