p-chlorophenyl dichlorophosphite | 32666-92-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-chlorophenyl dichlorophosphite
• 英文别名: dichloro-(4-chlorophenoxy)phosphane
• CAS: 32666-92-5
• 化学式: C₆H₄Cl₃OP
• 分子量: 229.43
• InChiKey: PIMBQOMNSAWHJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  p-chlorophenyl dichlorophosphite 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 2-(4-chlorophenoxy)-3-(3-chlorophenyl)-N-(4-nitrobenzyl)-3,4-dihydro-2H-2l5-benzo[e][1,3,2]oxazaphosphinin-2-imine
  参考文献：
  名称：

  N-[2-(4-卤代苯氧基)-3-(3-氯苯基)-3, 4-dihydro-2H-1,3,2-λ5-benzoxazaphosphinin-2-yliden]-N-取代的合成及光谱表征施陶丁格反应生成的胺

  摘要：

  AbstractThe synthesis of the title compounds was accomplished in four steps. The synthetic route involves the preparation of Schiff's base by reacting salicylaldehyde with m‐chloroaniline in EtOH. The Schiff's base was then reduced with NaBH4/MeOH. In the second step, PCl3 was reacted with p‐chlorophenol/p‐bromophenol in THF in the presence of Et3N to obtain P(III) dichloride derivatives. The reduced Schiff's base and dichloride derivatives were reacted in equimolar quantities in the presence of Et3N in THF to get the cyclized product. Alkyl azides were prepared by reacting alkyl bromides with sodium azide, and then alkyl azides were treated with the cyclized product to obtain the title compounds. The structure of these novel compounds was elucidated by elemental analysis, IR, 1H, 13C, 31P NMR, and mass spectroscopy. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:499–504, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20639

  DOI：

  10.1002/hc.20639
• 作为产物：
  描述：

  对氯苯酚 在 三氯化磷 作用下， 生成 p-chlorophenyl dichlorophosphite
  参考文献：
  名称：

  Strecker; Grossmann, Chemische Berichte, 1916, vol. 49, p. 75

  摘要：

  DOI：

文献信息

• [EN] CYCLIC PHOSPHATE SUBSTITUTED NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF LIVER DISEASES<br/>[FR] DÉRIVÉS DE NUCLÉOSIDES CYCLIQUES À SUBSTITUTION PHOSPHATE POUR LE TRAITEMENT DE MALADIES HÉPATIQUES
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：WO2018091542A1

  公开（公告）日：2018-05-24

  The present invention relates to Compounds of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, solvate or enantiomer thereof, wherein A, B, R1, R2, R3, R4, Q and V are as defined herein. The present invention also relates to pharmaceutical compositions comprising a Compound of Formula (I) or Formula (II) and to their use in therapy.

  本发明涉及式（I）或式（II）的化合物或其药用可接受的盐、溶剂化合物或对映体，其中A、B、R1、R2、R3、R4、Q和V如本文所定义。本发明还涉及包括式（I）或式（II）的化合物的药物组合物，并其在治疗中的应用。
• Nouvelle synthese simple de deoxtribonucledside-3′-aryl-β-cyanoethyl-phosphates
  作者：N.T. Thuong、M. Chassignol、C. Barbier

  DOI：10.1016/0040-4039(81)80013-5

  日期：1981.1

  The deoxyribonucleoside-3′-aryl-β-cyanoethyl-phosphates, very used in the synthesis of oligodeoxynucleotides, were synthesized in high yields in a single step from the nucleoside derivatives with a monofunctional phosphorylating agent : cyclohexylammonium p-chlorophenyl-β-cyanoethyl-phosphate.

  脱氧核糖核苷3'-芳基-β-氰基乙基磷酸酯是非常有用的寡聚脱氧核苷酸的合成方法，可通过单官能磷酸化试剂从核苷衍生物一步一步高收率地合成：磷酸盐。
• Strecker; Grossmann, Chemische Berichte, 1916, vol. 49, p. 75
  作者：Strecker、Grossmann

  DOI：——

  日期：——
• Dismutation of Diamidoarylphosphites
  作者：Edward E. Nifantyev、Elena N. Rasadkina、Pavel V. Slitikov、Larisa K. Vasyanina

  DOI：10.1080/714040960

  日期：2003.11.1

  Some examples of spontaneous dismutation of diamidoarylphosphites in different solvents were studied, and features of the process were revealed.
• Dismutation of arylene phosphorodiamidites: Specific features and aspects of preparative use
  作者：E. N. Rasadkina、P. V. Slitikov、E. E. Nifant’ev

  DOI：10.1134/s1070363206020046

  日期：2006.2

  The dismutation ofarylene phosphorodiamidites derived from the simplest phenols and naphthols and of their dibasic analogs was studied. The main regular trends of this process and the limits of its synthetic applicability were determined.