tert-butyl N-[(2E)-2-(hydroximino)-2-phenylethyl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[(2E)-2-(hydroximino)-2-phenylethyl]carbamate
• 英文别名: (2-Hydroxyimino-2-phenyl-ethyl)-carbamic acid tert-butyl ester；tert-butyl N-[(2Z)-2-hydroxyimino-2-phenylethyl]carbamate
• 化学式: C₁₃H₁₈N₂O₃
• 分子量: 250.298
• InChiKey: OYCHXXYYNVNOEE-RVDMUPIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  70.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  E-oxime of 2-[(triphenylphosphoranylidene)amino]acetophenone 、 二碳酸二叔丁酯 在 水 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以65%的产率得到tert-butyl N-[(2E)-2-(hydroximino)-2-phenylethyl]carbamate
  参考文献：
  名称：

  Syntheses based on α-azidooximes: I. Reduction of α-azidooximes

  摘要：

  Convenient procedures were developed for selective and exhaustive reduction of alpha-azido-oximes that were easily prepared from aliphatic nitro compounds. Nitroalkanes were shown to be convenient precursors of beta-functionalized amines (1,2-diamines, iminophosphonates, beta azidohydroxyl-amines, alpha-aminooximes).

  DOI：

  10.1134/s1070428007080027

文献信息

• Syntheses based on α-azidooximes: I. Reduction of α-azidooximes
  作者：A. Yu. Sukhorukov、A. N. Semakin、A. V. Lesiv、Yu. A. Khomutova、S. L. Ioffe

  DOI：10.1134/s1070428007080027

  日期：2007.8

  Convenient procedures were developed for selective and exhaustive reduction of alpha-azido-oximes that were easily prepared from aliphatic nitro compounds. Nitroalkanes were shown to be convenient precursors of beta-functionalized amines (1,2-diamines, iminophosphonates, beta azidohydroxyl-amines, alpha-aminooximes).