1-(propylamino)butan-2-ol | 90434-38-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(propylamino)butan-2-ol
• 英文别名: 1-Propylamino-2-butanol
• CAS: 90434-38-1
• 化学式: C₇H₁₇NO
• 分子量: 131.218
• InChiKey: PYEFENGRLHWSIJ-UHFFFAOYSA-N

物化性质

• 沸点：
  211.7±13.0 °C(Predicted)
• 密度：
  0.870±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-氨基-3-(3-甲基苯基）-1-丙醇 、 1-(propylamino)butan-2-ol 在 C₃₀H₄₃F₃IrN₅P₂ 、 sodium t-butanolate 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以93%的产率得到2-ethyl-N-propyl-6-p-tolylpyridin-3-amine
  参考文献：
  名称：

  β-和γ-氨基醇的选择性脱氢杂缩合反应合成亚功能化吡啶

  摘要：

  将醇转化为重要化合物类别的新反应变得越来越重要，因为它们的发展有助于保护我们的化石碳原料并减少CO 2排放。催化醇转化的两个关键概念是借用氢或氢的自动转移和无受体的脱氢缩合反应。在这里，我们结合了两个概念来合成间功能化的吡啶。首先，将二醇和胺与β-氨基醇连接，然后可以与γ-氨基醇进行选择性脱氢杂缩反应。PN 5稳定的铱催化剂我们实验室开发的P钳配体最有效地介导了反应。所有3氨基吡啶，我们在本文中描述的被合成的第一次，强调这种方法的创新程度和与该合成相关的问题元-功能化吡啶。

  DOI：

  10.1002/anie.201610071
• 作为产物：
  描述：

  1,2-环氧丁烷 、 正丙胺 以 水 为溶剂， 生成 1-(propylamino)butan-2-ol
  参考文献：
  名称：

  Amines Derived from Dihalopropenes. IV. The Absolute Configurations of the 1-(2-Methylene-1-aziridinyl)-3-buten-2-ols¹

  摘要：

  DOI：

  10.1021/jo01036a036

文献信息

• RUTHENIUM COMPOUND, MATERIAL FOR THIN FILM FORMATION, AND PROCESS FOR THIN FILM FORMATION
  申请人：ADEKA CORPORATION

  公开号：US20160272664A1

  公开（公告）日：2016-09-22

  Disclosed is a ruthenium compound useful as a precursor in chemical vapor growth, particularly ALD. The compound has good reactivity with a reactive gas, a high vapor pressure, and a low melting point. The compound is represented by general formula (I), wherein R 1 , R 2 , and R 3 each independently represent a straight or branched chain alkyl group having 1 to 5 carbon atoms, provided that the total number of the carbon atoms of R 1 and R 2 is 3 to 10. In formula (I), R 1 and R 2 are each preferably ethyl or isopropyl.

  本发明涉及一种钌化合物，可用作化学气相生长（特别是ALD）的前体。该化合物与反应气体具有良好的反应性，具有高蒸气压和低熔点。该化合物由通式（I）表示，其中R1，R2和R3各自独立地表示具有1至5个碳原子的直链或支链烷基，前提是R1和R2的碳原子总数为3至10。在式（I）中，R1和R2最好分别为乙基或异丙基。
• COPPER COMPOUND, STARTING MATERIAL FOR FORMING THIN FILM AND METHOD FOR PRODUCING THIN FILM
  申请人：Adeka Corporation

  公开号：EP3144293A1

  公开（公告）日：2017-03-22

  This invention provides a copper compound represented by General Formula (I) below. In General Formula (I), R1 to R3 independently represent a linear or branched alkyl group with a carbon number of 1 to 5; provided that R1 and R2 are a methyl group, R3 represents a linear or branched alkyl group with a carbon number of 2 to 5; and provided that R1 is a methyl group and R2 is an ethyl group, R3 represents a methyl group or a linear or branched alkyl group with a carbon number of 3 to 5. A starting material for forming a thin film of the present invention includes the copper compound represented by General Formula (I). The present invention can provide a copper compound which has a low melting point, can be conveyed in a liquid state, has a high vapor pressure, and is easily vaporizable, and also a starting material for forming a thin film which uses such a copper compound.

  本发明提供了由下式（I）表示的铜化合物。在通式（I）中，R1 至 R3 独立地代表碳原子数为 1 至 5 的直链或支链烷基；如果 R1 和 R2 是甲基，R3 代表碳原子数为 2 至 5 的直链或支链烷基；如果 R1 是甲基，R2 是乙基，R3 代表甲基或碳原子数为 3 至 5 的直链或支链烷基。用于形成本发明薄膜的起始材料包括通式（I）所代表的铜化合物。本发明可提供一种熔点低、能以液态输送、蒸汽压高且易汽化的铜化合物，以及一种使用这种铜化合物形成薄膜的起始材料。
• COBALT COMPOUND, RAW MATERIAL FOR FORMING THIN FILM, AND METHOD FOR PRODUCING THIN FILM
  申请人：Adeka Corporation

  公开号：EP3144313A1

  公开（公告）日：2017-03-22

  The cobalt compound of this invention is represented by general formula (I) below. In general formula (I), R1 to R3 independently represent a straight chain or branched alkyl group having 1 to 5 carbon atoms. In addition, the thin film-forming raw material of this invention contains the cobalt compound represented by general formula (I). According to this invention, it is possible to provide a cobalt compound which can be transported in the form of a liquid due to having a low melting point, which can be decomposed at a low temperature and which can be easily vaporized due to having a high vapor pressure; and a thin film-forming raw material that uses this cobalt compound.

  本发明的钴化合物由以下通式 (I) 表示。在通式（I）中，R1 至 R3 分别代表具有 1 至 5 个碳原子的直链或支链烷基。此外，本发明的成膜原料还含有通式（I）表示的钴化合物。根据本发明，可以提供一种钴化合物，该钴化合物因熔点低而可以液体形式运输，因蒸汽压高而可以在低温下分解并容易汽化；还可以提供一种使用该钴化合物的成膜原料。
• N-SUBSTITUTED ACYCLIC ETHYLENE DIAMINES
  申请人：Taminco bvba

  公开号：EP3290401A1

  公开（公告）日：2018-03-07

  Two alternative methods for producing at least one N-substituted acyclic ethylene diamine are provided: Method A according to the invention comprises: - reacting at least one reducing sugar, hydrogen and at least one primary amine NH2R or at least one secondary amine NHR'R" or a mixture of at least one primary amine NH2R and at least one secondary amine NHR'R" - in the presence of a supported hydrogenation catalyst - at a reaction temperature of 50°C to 200 °C, and - at a reaction pressure being superatmospheric pressure, and wherein - the molar ratio of the at least one primary amine and/or secondary amine : reducing sugar is at least 4:1. Method B according to the invention comprises the steps: 1. reacting at least one reducing sugar and at least one primary amine NH2R or at least one secondary amine NH2R'R" or a mixture of at least one primary amine NH2R and at least one secondary amine NHR'R" in a first step, and 2. reacting the reaction mixture obtained in step 1) with hydrogen in the presence of a supported hydrogenation catalyst in a second step.

  本发明提供了生产至少一种 N-取代无环乙二胺的两种替代方法： 根据本发明的方法 A 包括 - 使至少一种还原糖、氢和至少一种伯胺 NH2R 或至少一种仲胺 NHR'R" 或至少一种伯胺 NH2R 和至少一种仲胺 NHR'R" 的混合物反应 - 在支撑氢化催化剂存在下 - 反应温度为 50°C 至 200°C，以及 - 反应压力为超大气压，其中 - 至少一种伯胺和/或仲胺与还原糖的摩尔比至少为 4:1。 根据本发明的方法 B 包括以下步骤 在第一步中使至少一种还原糖和至少一种伯胺 NH2R 或至少一种仲胺 NH2R'R" 或至少一种伯胺 NH2R 和至少一种仲胺 NHR'R" 的混合物反应，以及 2. 在第二步中，将步骤 1) 中得到的反应混合物在有支撑氢化催化剂存在的情况下与氢气反应。
• ARYL SUBSTITUTED CARBOXAMIDE DERIVATIVES AS CALCIUM OR SODIUM CHANNEL BLOCKERS
  申请人：RaQualia Pharma Inc.

  公开号：EP3632899A1

  公开（公告）日：2020-04-08

  The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.

  本发明涉及式(I)的芳基取代的羧酰胺衍生物或其药学上可接受的盐，它们作为对河豚毒素敏感的(TTX-S)阻断剂，如NaV1.3和NaV1.7，具有阻断T型钙通道或电压门控钠通道的活性，可用于治疗或预防涉及T型钙通道或电压门控钠通道的紊乱和疾病。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗涉及 T 型钙通道或电压门控钠通道的此类疾病中的用途。