2-amino-9-benzyl-6-(ethylamino)purine | 1268633-87-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-amino-9-benzyl-6-(ethylamino)purine
• 英文别名: 9-benzyl-6-N-ethylpurine-2,6-diamine
• CAS: 1268633-87-9
• 化学式: C₁₄H₁₆N₆
• 分子量: 268.321
• InChiKey: AOIBKOQTOXRMMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  81.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-甲酰乙胺 、 9-苄基-6-氯嘌呤-2-胺 以 甲苯 为溶剂， 反应 1.03h， 以59%的产率得到2-amino-9-benzyl-6-(ethylamino)purine
  参考文献：
  名称：

  The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines

  摘要：

  The microwave-assisted decomposition of DMF was thoroughly studied and the reaction conditions (temperature, solvent effect, and effect of additives, such as acids, bases, and salts) were optimized for its use in amination reactions. The applicability of this expedient methodology in purine chemistry and with various formamides is demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.040

文献信息

• The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines
  作者：Lucie Čechová、Petr Jansa、Michal Šála、Martin Dračínský、Antonín Holý、Zlatko Janeba

  DOI：10.1016/j.tet.2010.12.040

  日期：2011.2

  The microwave-assisted decomposition of DMF was thoroughly studied and the reaction conditions (temperature, solvent effect, and effect of additives, such as acids, bases, and salts) were optimized for its use in amination reactions. The applicability of this expedient methodology in purine chemistry and with various formamides is demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.