2,3,4,5,6-pentafluorophenyl 2-(5,7,8-trimethyl-1,3-dioxo-2,5-dihydro-2,4-diazaphenazin-2-yl)acetate | 340259-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 2,3,4,5,6-pentafluorophenyl 2-(5,7,8-trimethyl-1,3-dioxo-2,5-dihydro-2,4-diazaphenazin-2-yl)acetate
• 英文别名: (2,3,4,5,6-Pentafluorophenyl) 2-(7,8,10-trimethyl-2,4-dioxobenzo[g]pteridin-3-yl)acetate
• CAS: 340259-04-3
• 化学式: C₂₁H₁₃F₅N₄O₄
• 分子量: 480.351
• InChiKey: YLHLLACKQMNEQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  91.6
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  ([2-[(叔丁氧羰基)氨基]乙基]氨基)乙酸 、 2,3,4,5,6-pentafluorophenyl 2-(5,7,8-trimethyl-1,3-dioxo-2,5-dihydro-2,4-diazaphenazin-2-yl)acetate 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以96%的产率得到2-(N-(2-((t-butoxy)carbonylamino)ethyl))-2-(5,7,8-trimethyl-1,3-dioxo(2,5-dihydro-2,4-diazaphenazin-2-yl)acetylamino)acetic acid
  参考文献：
  名称：

  Synthesis and characterization of flavin-tethered peptide nucleic acid

  摘要：

  We synthesized flavin-containing PNA. monomer unit 5 from lumiflavin and prepared PNAs containing a flavin moiety (FPNA) by the standard tBoc chemistry. Each PNA oligomer was purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses indicated that the PNA oligomer containing a flavin moiety near the amino terminal considerably stabilized the PNA-DNA hybrids. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00228-3
• 作为产物：
  描述：

  光黃素 在 potassium carbonate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 盐酸 、 N,N-二甲基甲酰胺 为溶剂， 反应 54.0h， 生成 2,3,4,5,6-pentafluorophenyl 2-(5,7,8-trimethyl-1,3-dioxo-2,5-dihydro-2,4-diazaphenazin-2-yl)acetate
  参考文献：
  名称：

  Synthesis and characterization of flavin-tethered peptide nucleic acid

  摘要：

  We synthesized flavin-containing PNA. monomer unit 5 from lumiflavin and prepared PNAs containing a flavin moiety (FPNA) by the standard tBoc chemistry. Each PNA oligomer was purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses indicated that the PNA oligomer containing a flavin moiety near the amino terminal considerably stabilized the PNA-DNA hybrids. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00228-3

文献信息

• Novel functional peptide nucleic acid monomer and process for producing the same
  申请人：——

  公开号：US20040101839A1

  公开（公告）日：2004-05-27

  A compound represented by general formula (I) below; 1 (in the formula, A denotes 2 3 4 5 B denotes 6 R denotes H, NO 2 , NH 2 , NHCbz, Br, F, Cl or SO 3 Na 2 , and n is an integer of 1 to 4), and a process for producing the above compound characterised in that it includes a reaction between an activated ester and a t-butoxycarbonylaminoethylamine or an &ohgr;-amino acid derivative. 7

  化合物的一般式（I）如下所示；1（在公式中，A表示2345，B表示6，R表示H，NO2，NH2，NHCbz，Br，F，Cl或SO3Na2，n是1到4的整数），以及一种制备上述化合物的方法，其特征在于它包括活性酯与t-叔丁氧羰基氨乙基胺或&ohgr;-氨基酸衍生物之间的反应。7
• Novel Functional Peptide Nucleic Acid Monomer and Process for Producing the Same
  申请人：Ikeda Hisafumi

  公开号：US20080138817A1

  公开（公告）日：2008-06-12

  A compound represented by general formula (I) below; (in the formula, A denotes B denotes R denotes H, NO 2 , NH 2 , NHCbz, Br, F, Cl or SO 3 Na 2 , and n is an integer of 1 to 4 ), and a process for producing the above compound characterised in that it includes a reaction between an activated ester and a t-butoxycarbonylaminoethylamine or an ω-amino acid derivative.

  以下是一种由通式（I）表示的化合物；（在公式中，A代表B代表R代表H，NO2，NH2，NHCbz，Br，F，Cl或SO3Na2，n是1到4的整数），以及一种生产上述化合物的过程，其特征在于它包括激活酯和t-丁氧羰基氨乙胺或ω-氨基酸衍生物之间的反应。
• NOVEL FUNCTIONAL PEPTIDE NUCLEIC ACID MONOMER AND PROCESS FOR PRODUCING THE SAME
  申请人：Applied Biosystems Japan Ltd.

  公开号：EP1357112A1

  公开（公告）日：2003-10-29

  A compound represented by general formula (I) below; (in the formula, A denotes B denotes R denotes H, NO2, NH2, NHCbz, Br, F, Cl or SO3Na2, and n is an integer of 1 to 4), and a process for producing the above compound characterised in that it includes a reaction between an activated ester and a t-butoxycarbonylaminoethylamine or an ω-amino acid derivative.

  由以下通式(I)代表的化合物； (式中，A 表示 B 表示 R表示H、NO2、NH2、NHCbz、Br、F、Cl或SO3Na2，n为1至4的整数），以及生产上述化合物的工艺，其特征在于它包括活化酯与t-丁氧羰基氨基乙胺或ω-氨基酸衍生物之间的反应。
• EP1357112
  申请人：——

  公开号：——

  公开（公告）日：——
• US7282575B2
  申请人：——

  公开号：US7282575B2

  公开（公告）日：2007-10-16