4-(ethoxycarbonyl)benzanilide | 78823-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(ethoxycarbonyl)benzanilide
• 英文别名: ethyl phenyl terephthalate；Ethyl 4-(phenylcarbamoyl)benzoate
• CAS: 78823-42-4
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: XQHVAXQGFFPHLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-乙氧酰基重氮苯四氟硼酸盐 在 palladium diacetate 作用下， 以 乙腈 为溶剂， 25.0 ℃ 、882.54 kPa 条件下， 反应 2.5h， 生成 4-(ethoxycarbonyl)benzanilide
  参考文献：
  名称：

  Reaction of diazonium salts with transition metals. 6. Preparation of mixed acid anhydrides from arenediazonium salts and sodium carboxylates under palladium(0) catalysis

  摘要：

  DOI：

  10.1021/jo00335a018

文献信息

• Cobalt carbonyl as an effective CO source in one-pot synthesis of esters from aryl halides
  作者：P. Baburajan、R. Senthilkumaran、Kuppanagounder P. Elango

  DOI：10.1039/c3nj00548h

  日期：——

  For the first time, we have successfully applied Co2(CO)8 as an effective carbonyl source for the Pd catalysed alkoxycarbonylation of aryl halides affording the corresponding aryl esters under mild microwave conditions. A wide variety of esters and carbonyl derivatives were prepared using this protocol.

  首次成功地将Co2(CO)8作为有效的羰基源用于Pd催化下温和微波条件中的芳基卤化物的烷氧羰基化反应，合成了相应的芳基酯。利用这一方案，制备了多种酯和羰基衍生物。
• Bis(cyclopentadienyldicarbonyliron) as a Convenient Carbon Monoxide Source in Palladium-catalyzed Carbonylative Coupling of Aryl Iodides with Amines, Alcohols, and Thiols
  作者：Ryotaro Nakaya、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1246/cl.2011.904

  日期：2011.9.5

  Bis(cyclopentadienyldicarbonyliron) ([CpFe(CO)2]2) serves as a carbon monoxide source in carbonylative coupling reactions. Treatment of aryl iodides with primary amines in the presence of DBU and [...

  双(环戊二烯基二羰基铁) ([CpFe(CO)2]2) 在羰基化偶联反应中用作一氧化碳源。在 DBU 和 [...] 存在下用伯胺处理芳基碘化物
• Highly Efficient Aminocarbonylation of Iodoarenes at Atmospheric Pressure Catalyzed by a Robust Acenaphthoimidazolyidene Allylic Palladium Complex
  作者：Weiwei Fang、Qinyue Deng、Mizhi Xu、Tao Tu

  DOI：10.1021/ol401550h

  日期：2013.7.19

  A robust allylic palladium-NHC complex was developed and exhibited extremely high catalytic activity toward aminocarbonylation of various (hetero)aryl iodides under atmospheric carbon monoxide pressure, in which a broad range of secondary and primary amines were well tolerated. In addition, the concise synthesis of an anticancer drug tamibarotene was accomplished even in a gram scale, further highlighting the practical applicability of the protocol.