(E)-4-chloro-2-(2-(2-chlorobenzylidene)hydrazinyl)pyridine | 1258542-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-4-chloro-2-(2-(2-chlorobenzylidene)hydrazinyl)pyridine
• 英文别名: 4-chloro-N-[(E)-(2-chlorophenyl)methylideneamino]pyridin-2-amine
• CAS: 1258542-95-8
• 化学式: C₁₂H₉Cl₂N₃
• 分子量: 266.13
• InChiKey: KKNVDVNISAVFAR-LZYBPNLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-4-chloro-2-(2-(2-chlorobenzylidene)hydrazinyl)pyridine 在 2-双环己基膦-2',6'-二甲氧基联苯 、 potassium phosphate 、 palladium diacetate 、 chloramine T trihydrate 作用下， 以 2-甲基四氢呋喃 、 水 、 异丙醇 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Palladium-Catalyzed Triazolopyridine Synthesis: Synthesis of 7-Chloro-3-(2-Chlorophenyl)-1,2,4-Triazolo[4,3-a]Pyridine

  摘要：

  Chloramine-T is thermally unstable and heating of chloramines-T beyond the temperature disclosed in this procedure should not be conducted without further safety evaluation. Hydrazine should be handled in a fume hood as it is an animal carcinogen and has been identified it as a potential human carcinogen. In addition, anhydrous hydrazine is potentially explosive, especially in contact with metals, and should only be handled as its hydrate.

  DOI：

  10.15227/orgsyn.090.0287
• 作为产物：
  描述：

  2-氯苯甲醛 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 hydrazine hydrate 、 potassium carbonate 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 1.0h， 生成 (E)-4-chloro-2-(2-(2-chlorobenzylidene)hydrazinyl)pyridine
  参考文献：
  名称：

  Palladium-Catalyzed Triazolopyridine Synthesis: Synthesis of 7-Chloro-3-(2-Chlorophenyl)-1,2,4-Triazolo[4,3-a]Pyridine

  摘要：

  Chloramine-T is thermally unstable and heating of chloramines-T beyond the temperature disclosed in this procedure should not be conducted without further safety evaluation. Hydrazine should be handled in a fume hood as it is an animal carcinogen and has been identified it as a potential human carcinogen. In addition, anhydrous hydrazine is potentially explosive, especially in contact with metals, and should only be handled as its hydrate.

  DOI：

  10.15227/orgsyn.090.0287

文献信息

• Palladium-Catalyzed Coupling of Aldehyde-Derived Hydrazones: Practical Synthesis of Triazolopyridines and Related Heterocycles
  作者：Oliver R. Thiel、Michal M. Achmatowicz、Andreas Reichelt、Robert D. Larsen

  DOI：10.1002/anie.201001999

  日期：2010.11.2

  The palladium‐catalyzed intermolecular coupling of aldehyde‐derived hydrazones with chloroazines, followed by oxidative cyclization under mild conditions afforded access to a broad variety of bicyclic heterocyclic scaffolds (see scheme) that have potential for use in drug discovery.

  钯催化的醛衍生的azo酮与氯嗪的分子间偶联，然后在温和的条件下进行氧化环化，可以使用各种各样的双环杂环骨架（参见方案），这些骨架可能会用于药物发现。
• Imidazo- and triazolo-pyridine compounds and methods of use thereof
  申请人：Zhang Dawei

  公开号：US20080161303A1

  公开（公告）日：2008-07-03

  The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, B, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

  本发明涉及一类新的化合物，用于预防和治疗与蛋白激酶介导的疾病有关的疾病，包括炎症和相关病症。这些化合物具有通用的I式，其中A、B、R1、R2、R3和R4在此处被定义。该发明还涵盖包括I式中的一个或多个化合物的制药组合物，以及用于治疗P38地图激酶介导的疾病，包括类风湿性关节炎、牛皮癣和其他炎症性疾病的化合物和组合物的用途，以及用于制备I式化合物的中间体和工艺。
• IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF
  申请人：Amgen Inc.,

  公开号：EP2086973B1

  公开（公告）日：2012-01-25
• US7700593B2
  申请人：——

  公开号：US7700593B2

  公开（公告）日：2010-04-20
• [EN] IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF<br/>[FR] COMPOSÉS D'IMIDAZO- ET DE TRIAZOLO-PYRIDINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2008045393A2

  公开（公告）日：2008-04-17

  [EN] The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have general Formula (I), wherein A, B, R¹, R², R³ and R⁴ are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula (I).
  [FR] La présente invention concerne une nouvelle classe de composés utile pour la prophylaxie et le traitement de maladies favorisées par la protéine kinase, y compris l'inflammation et les états pathologiques liés. Les composés sont représentés par la formule générale (I), dans laquelle A, B, R¹, R², R³ et R⁴ sont tels que définis ici. L'invention concerne également des compositions pharmaceutiques incluant un ou plusieurs composé(s) représenté(s) par la formule (I), l'utilisation de ces composés et compositions pour le traitement de maladies favorisées par la P38 map kinase, y compris la polyarthrite rhumatoïde, le psoriasis et d'autres troubles inflammatoires, ainsi que des intermédiaires et des procédés utiles pour la préparation des composés représentés par la formule (I).