2-Dimethylamino-pyridin-1-oxid | 3618-79-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Dimethylamino-pyridin-1-oxid
• 英文别名: 2-Dimethylamino-pyridin-N-oxid；N,N-Dimethyl-2-pyridinamine, 1-oxide；N,N-dimethyl-1-oxidopyridin-1-ium-2-amine
• CAS: 3618-79-9
• 化学式: C₇H₁₀N₂O
• 分子量: 138.169
• InChiKey: ALYWTLHMUXJVIR-UHFFFAOYSA-N

物化性质

• 熔点：
  59-60 °C(Solv: benzene (71-43-2))
• 沸点：
  143-145 °C(Press: 0.25 Torr)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  28.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Dimethylamino-pyridin-1-oxid 以26%的产率得到
  参考文献：
  名称：

  PAUDLER, W. W.;JOVANOVIC, M. V., J. ORG. CHEM., 1983, 48, N 7, 1064-1069

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯吡啶 在 双氧水 、 溶剂黄146 作用下， 生成 2-Dimethylamino-pyridin-1-oxid
  参考文献：
  名称：

  33. 2-氨基吡啶1-氧化物的结构和反应活性

  摘要：

  DOI：

  10.1039/jr9570000191

文献信息

• Infrared and thermal studies of tin(IV) halide complexes of substituted amino pyridine N-oxides
  作者：R.K. Agarwal、H.K. Rawat

  DOI：10.1016/0040-6031(85)87116-1

  日期：1985.8

  Spectres IR et caracteristiques de decomposition des complexes halogenures de Sn(IV) et N-oxydes de methyl-2 et dimethylamino-2 pyridine

  Specters IR et caracteristiques de decommissiones decomplexes haloures de Sn(IV) et N-oxydes demethyl-2 et 二甲氨基-2pyridine
• Copper(II) complexes of N,N-dimethyl-2-picolinamine N-oxide
  作者：Douglas X. West、Rolfe J. Hartley

  DOI：10.1016/0022-1902(80)80218-1

  日期：1980.1

  Cu(II) complexes have been prepared with N,N-dimethyl-2-picolinamine N-oxide (DMA) employing the tetrafluoroborate, nitrate, chloride and bromide salts. Complexes having 1:2 and 1:1 metal ion to ligand ratios have been isolated. Characterization has been accomplished by IR, electronic and ESR spectral measurements of the solid state. Significant changes occurred when spectral measurements of acetonitrile

  已使用四氟硼酸盐，硝酸盐，氯化物和溴化物盐与N，N-二甲基-2-吡啶甲酸胺N-氧化物（DMA）制备了Cu（II）配合物。已经分离出具有1：2和1：1的金属离子与配体比率的配合物。表征已通过红外，电子和ESR固态光谱测量完成。尝试对各种固体的乙腈溶液进行光谱测量时，发生了显着变化，表明发生了Cu（II）键的变化。包括固体的热数据。
• 2-dimethyl- and 2-diethylaminopyridine N-oxide complexes prepared from various cobalt(II) salts
  作者：Douglas X. West、Herbert M. Nowak

  DOI：10.1016/0022-1902(81)80605-7

  日期：1981.1

  2-dimethyl- and 2-diethylaminopyridine N-oxide (DM and DE, respectively) complexes have been formed with CoX2 (X=ClO4, BF4, NO3 and Cl). Although preparative ligand: Co(II) mole ratios were varied, only one unique solid was isolated for each ligand and cobalt salt combination. Characterization of the eight solids was accomplished primarily by partial elemental analyses and infrared and electronic spectra

  已经与CoX 2（X ＝ ClO 4，BF 4，NO 3和Cl）形成了2-二甲基和2-二乙基氨基吡啶N-氧化物（分别为DM和DE）配合物。尽管制备的配体：Co（II）的摩尔比有所变化，但每种配体和钴盐组合仅分离出一种独特的固体。八个固体的表征主要通过部分元素分析以及红外和电子光谱来完成。与2-甲基氨基吡啶的N-氧化物相比，这两个二烷基配体都倾向于作为二齿配体键合，尽管某些配合物似乎具有以单齿和双齿方式结合的N-氧化物。
• Method for Producing Optically Active Alpha-Ionone
  申请人：Yamamoto Tetsuya

  公开号：US20090216039A1

  公开（公告）日：2009-08-27

  Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.

  提供一种以低成本高产率和高对映选择性的方法制备光学活性α-离子酮，并在短时间内具有良好的可操作性，以及包括上述方法获得的光学活性α-离子酮的香水组合物。一种制备光学活性α-离子酮的方法，包括将光学异构体混合物α-离子酮与酯化剂反应，并水解所得的α-离子酮烯醇酯；一种制备光学活性α-离子酮的方法，包括将光学异构体混合物α-离子酮进行不对称还原，使得所得的光学活性α-离子醇与酯化剂反应，得到光学活性α-离子醇酯，必要时纯化后水解所得的光学活性α-离子醇酯，然后氧化所得的光学活性α-离子醇；以及包括上述所得光学活性α-离子酮的香水组合物。
• METHOD FOR PRODUCING OPTICALLY ACTIVE a-IONONE
  申请人：Yamamoto Tetsuya

  公开号：US20110118500A1

  公开（公告）日：2011-05-19

  Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.

  提供一种廉价高产、高对映选择性并具有良好可操作性的短流程制备光学活性α-离子酮的方法，以及包含上述方法得到的光学活性α-离子酮的香料组合物。制备光学活性α-离子酮的方法包括将光学异构体混合物的α-离子酮与酯化试剂反应，并水解所得的α-离子酮烯醇酯；制备光学活性α-离子酮的方法包括将光学异构体混合物的α-离子酮进行不对称还原，使所得的光学活性α-离子醇与酯化试剂反应以得到光学活性α-离子醇酯，在必要时经过纯化后水解所得的光学活性α-离子醇酯，然后将所得的光学活性α-离子醇进行氧化；以及包含所得光学活性α-离子酮的香料组合物。