溴吡斯的明相关化合物B(USP) | 4685-07-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 溴吡斯的明相关化合物B(USP)
• 英文名称: 1-Methyl-3-hydroxy-pyridinium
• 英文别名: N-Methyl-3-hydroxy-pyridinium；1-Methylpyridin-1-ium-3-ol
• CAS: 4685-07-8
• 化学式: C₆H₈NO
• mdl: MFCD00971955
• 分子量: 110.136
• InChiKey: FZVAZYLFYPULKX-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  24.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  溴吡斯的明相关化合物B(USP) 以 水 为溶剂， 生成 1-甲基-3-吡啶酮
  参考文献：
  名称：

  邻近的电荷效应。4.在2-羟基-N，N，N-三甲基苯铵离子和3-羟基-N-甲基吡啶鎓离子去质子反应中反应热和反应物及产物的溶剂转移焓

  摘要：

  DOI：

  10.1021/j100231a028

文献信息

• [EN] ANTIMICROBIAL SALT FOR MEDICAL GLOVES<br/>[FR] SEL ANTIMICROBIEN POUR GANTS MÉDICAUX
  申请人：CHEMICAL INTELLIGENCE LTD

  公开号：WO2021001440A1

  公开（公告）日：2021-01-07

  A process for the manufacture of phthalocyanine pyridinium salt, wherein the process comprises: (a) reacting a phthalocyanine pyridinium with a methylating agent, and (b) ion exchanging with an anionic counterion.

  一种制备酞菁吡啶盐的工艺，其中该工艺包括：(a)将酞菁吡啶与甲基化试剂反应，以及(b)与阴离子对离子交换。
• ANTIMICROBIAL AND ANTICANCER CATIONIC PHTHALOCYANINE COMPOUNDS
  申请人：Chemical Intelligence Limited

  公开号：EP3553062A1

  公开（公告）日：2019-10-16

  Substituted phthalocyanines for the generation of singlet oxygen in which one or more of the substituents bear a cationically charged N-alkylated pyridine.

  用于产生单线态氧的取代酞菁，其中一个或多个取代基含有带阳离子的 N-烷基吡啶。
• New antiglioma zwitterionic pronucleotides with an FdUMP framework
  作者：Agnieszka Szymanska-Michalak、Dariusz Wawrzyniak、Grzegorz Framski、Jacek Stawinski、Jan Barciszewski、Adam Kraszewski

  DOI：10.1016/j.ejmech.2017.12.070

  日期：2018.1

  We have designed and synthesized new 5-fluoro-2'-deoxyuridine 5'-phosphate pronucleotides which can function as potential agents against the glioblastoma multiforme tumor. Their anti-malignant potency has been tested against T98G, U-118 MG, U-87 MG gliomas, HeLa, and Caco-2 cancer cell lines, using MRC-5 healthy cells as a reference. Five of the sixteen compounds (4c, 4f-i) exhibited significant anticancer potency and high selectivity indices (SI 12-66). It is likely that these zwitterionic pronucleotides may function in a similar manner to zwitterionic phospholipids, by inducing cell membrane charge disorder, making the cell permeable to bioactive agents. The most promising therapeutic pronucleotides 4c, 4f-h, have high intestinal-blood uptake potency (Caco-2 cell line), and may be considered as potential, orally administrated, anticancer drugs. (C) 2017 Elsevier Masson SAS. All rights reserved.
• USE OF PHTHALOCYANINE DERIVATES FOR THE NON-PHOTODYNAMIC TREATMENT OF DISEASES
  申请人：L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA' DI ESERCIZIO SOCIETA' PER AZIONI

  公开号：EP1904060B1

  公开（公告）日：2011-06-01
• US4042698A
  申请人：——

  公开号：US4042698A

  公开（公告）日：1977-08-16

表征谱图