2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene | 1004960-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene
• 英文别名: 2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-tert-butyldimethylsilylphenol；Tert-butyl-dimethyl-[2-(4-trimethylsilylbuta-1,3-diynyl)phenoxy]silane
• CAS: 1004960-33-1
• 化学式: C₁₉H₂₈OSi₂
• 分子量: 328.602
• InChiKey: XTZRUVZFIICSQT-UHFFFAOYSA-N

物化性质

• 沸点：
  355.8±44.0 °C(Predicted)
• 密度：
  0.94±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以70%的产率得到2-乙炔苯并呋喃
  参考文献：
  名称：

  A straightforward synthesis of indole and benzofuran derivatives

  摘要：

  A new methodology for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into new unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.10.100
• 作为产物：
  描述：

  (Trimethylsilyl)butadiyne 、 tert-butyl(2-iodophenoxy)dimethylsilane 在 四(三苯基膦)钯 copper(l) iodide 、 三乙胺 作用下， 反应 6.0h， 以88%的产率得到2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene
  参考文献：
  名称：

  A straightforward synthesis of indole and benzofuran derivatives

  摘要：

  A new methodology for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into new unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.10.100

文献信息

• A Straightforward Synthesis of Benzofuran- and Indole-Substituted 1,2,3-Triazoles via Click Chemistry
  作者：Vito Fiandanese、Daniela Bottalico、Giuseppe Marchese、Angela Punzi、Maria Quarta、Marianna Fittipaldi

  DOI：10.1055/s-0029-1217017

  日期：2009.11

  A convenient synthesis of benzofuran- and indole-substituted 1,2,3-triazoles has been devised starting from easily available 2-silylalkynyl-substituted benzofuran and indole derivatives.

  已设计出一种便利的合成方法，从易于获得的2-硅烷基炔基取代的苯并呋喃和吲哚衍生物出发，合成苯并呋喃和吲哚取代的1,2,3-三唑。
• A rapid synthesis of 2-alkynylindoles and 2-alkynylbenzofurans
  作者：Vito Fiandanese、Daniela Bottalico、Giuseppe Marchese、Angela Punzi

  DOI：10.1016/j.tet.2008.05.059

  日期：2008.7

  An expeditious synthesis of 2-alkynylindoles and 2-alkynylbenzofuran derivatives has been devised starting from easily available ortho-substituted aryl diynes. (c) 2008 Elsevier Ltd. All rights reserved.
• A straightforward synthesis of indole and benzofuran derivatives
  作者：Vito Fiandanese、Daniela Bottalico、Giuseppe Marchese、Angela Punzi

  DOI：10.1016/j.tet.2007.10.100

  日期：2008.1

  A new methodology for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into new unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives. (c) 2007 Elsevier Ltd. All rights reserved.