α-naphthylbenzylbromide | 199111-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: α-naphthylbenzylbromide
• 英文别名: 1-(α-bromo-benzyl)-naphthalene；1-(α-Brom-benzyl)-naphthalin；1-[Bromo(phenyl)methyl]naphthalene
• CAS: 199111-37-0
• 化学式: C₁₇H₁₃Br
• mdl: MFCD18576911
• 分子量: 297.194
• InChiKey: AJKIYPAKMVJZNY-UHFFFAOYSA-N

物化性质

• 沸点：
  397.1±11.0 °C(Predicted)
• 密度：
  1.370±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.058
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  acetylene-bis-magnesium bromide 、 α-naphthylbenzylbromide 生成 1,4-Diphenyl-1,4-di-<1-(1,2,3,4-tetrahydro-naphthyl>-butan
  参考文献：
  名称：

  Protonation and alkylation of dianions derived from 1,4-diphenyl-1,4-di(1-naphthyl)butatrriene, 2,5-diphenyl-2,3,4-hexatriene, 1,1,4-triphenyl-1,2,3-pentatriene, and 1,1-diphenyl-4-methyl-1,2,3-pentatriene

  摘要：

  DOI：

  10.1021/jo00822a034
• 作为产物：
  描述：

  萘-1-基(苯基)甲醇 在 乙酰溴 、 氢溴酸 、 溶剂黄146 作用下， 生成 α-naphthylbenzylbromide
  参考文献：
  名称：

  The Relative Stability of Penta-Arylethanes. I. The Preparation of Penta-Arylethanes

  摘要：

  DOI：

  10.1021/ja01332a061

文献信息

• (Z)-β-烯基溴多组分制备1,4-取代-1,2,3-三 氮唑的方法及应用
  申请人：乐山师范学院

  公开号：CN106866557B

  公开（公告）日：2019-11-12

  本发明具体涉及一种(Z)‑β‑烯基溴多组分制备1,4‑取代‑1,2,3‑三氮唑的方法及应用，属于1,4‑取代‑1,2,3‑三氮唑的制备技术领域。该方法为：以卤化物、叠氮试剂及(Z)‑β‑烯基溴为原料，加入铜催化剂和碱，于一定温度下，在溶剂中搅拌反应，反应结束后对产物进行分离提纯，即得所述1,4‑取代‑1,2,3‑三氮唑。本发明的合成方法使用的原料易得，成本低廉，反应条件温和，操作简便，产率高，反应过程绿色环保，适用于工业化生产。
• Catalyst Compounds and Use Thereof
  申请人：GIESBRECHT Garth R.

  公开号：US20110098431A1

  公开（公告）日：2011-04-28

  This invention relates to Group 4 dialkyl compounds supported by a pyridyl-amido-aryl (“PAA”), an anisole-amido-aryl (“AAA”), a phenoxy-amido-pyridyl (“PAPY”), an anisole-amido-phenoxy (“AAP”) or a anisole-amido-phenoxy (“AAP”) tridentate ligand. Such compounds can polymerize olefins, such as ethylene.

  本发明涉及由吡啶基氨基芳基（“PAA”）、甲氧基基氨基芳基（“AAA”）、苯氧基氨基吡啶基（“PAPY”）、甲氧基基氨基苯氧基（“AAP”）或甲氧基基苯氧基（“AAP”）三齿配体支撑的第四族二烷基化合物。这些化合物可以聚合烯烃，例如乙烯。
• Catalyst compounds and use thereof
  申请人：Giesbrecht Garth R.

  公开号：US08530593B2

  公开（公告）日：2013-09-10

  This invention relates to Group 4 dialkyl compounds supported by a pyridyl-amido-aryl (“PAA”), an anisole-amido-aryl (“AAA”), a phenoxy-amido-pyridyl (“PAPY”), an anisole-amido-phenoxy (“AAP”) or a anisole-amido-phenoxy (“AAP”) tridentate ligand. Such compounds can polymerize olefins, such as ethylene.

  本发明涉及由吡啶基氨基苯基（“PAA”）、甲氧基基氨基苯基（“AAA”）、苯氧基氨基吡啶基（“PAPY”）、甲氧基基氨基苯氧基（“AAP”）或甲氧基基苯氧基（“AAP”）三牙配体支持的第四族二烷基化合物。此类化合物可以聚合烯烃，例如乙烯。
• Palladium-Catalyzed Methylation of Aryl and Vinyl Halides by Stabilized Methylaluminum and Methylgallium Complexes
  作者：Jochanan Blum、Dmitri Gelman、Waël Baidossi、Eduard Shakh、Ayelet Rosenfeld、Zeev Aizenshtat、Birgit C. Wassermann、Michael Frick、Bernd Heymer、Stefan Schutte、Sonja Wernik、Herbert Schumann

  DOI：10.1021/jo970822n

  日期：1997.12.1

  The intramolecularly stabilized mono-and dialkylaluminum complexes la, 2, 3, 4a, 5a, 5c, 6a, 6c, 7, 8, and 9 in the presence of palladium catalysts, cross-alkylate aryl, vinyl, and benzyl bromides and iodides under mild standard laboratory conditions. Aryl bromides with carbonyl substituents or benzylic halides are converted partially into dialkyl compounds. Under similar conditions, the analogous stabilized dimethylgallium complexes Ib, 4b, 5b, 6b, and 10 methylate aryl and vinyl bromides and iodides in a highly selective manner. Substituted bromobenzenes XC6H4Br, where X = CHO, COPh, CO2Et, CN, NO2, Cl, CH2Br, or CH=CHCOPh, are methylated by the organogallium reagents usually only at the aromatic ring halogen atom to give substituted toluenes as single products. The methylation rates were shown to depend on the nature of the chelating ligands, on the solvent, and on the type of palladium catalyst employed.
• SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists
  作者：Miguel Guerrero、Mariangela Urbano、Marie-Therese Schaeffer、Steven Brown、Hugh Rosen、Edward Roberts

  DOI：10.1016/j.bmcl.2012.12.030

  日期：2013.2

  In this Letter we report on the advances in our NPBWR1 antagonist program aimed at optimizing the 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy)pyridazin-3(2H)-one lead molecule previously obtained from a high-throughput screening (HTS)-derived hit. Synthesis and structure-activity relationships (SAR) studies around the 3,5-dimethylphenyl and 4-methoxyphenyl regions resulted in the identification of a novel series of non-peptidic submicromolar NPBWR1 antagonists based on a 5-chloro-4-(4-alkoxyphenoxy)-2-(benzyl)pyridazin-3(2H)-one chemotype. Amongst them, 5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)pyridazin-3(2H)-one 9h (CYM50769) inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-targets with pharmaceutical relevance. Our medicinal chemistry study provides innovative non-peptidic selective NPBWR1 antagonists that may enable to clarify the biological role and therapeutic utility of the target receptor in the regulation of feeding behavior, pain, stress, and neuroendocrine function. (c) 2012 Elsevier Ltd. All rights reserved.