Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/
/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ ... 5,5-Dimethylhydantoin (DMH) in Rats, Dantoin (DMH, purity = 99.8%) was fed in diet to CD rats (60/sex/dose) at 0 (2 control groups), 100, 300, or 1000 mg/kg/day for 104 weeks. Diets were adjusted periodically for DMH concentration to maintain the doses with separate diets for males and females. Chronic NOEL = 300 mg/kg/day (Survival time relative to controls was decreased in both sexes at 1000 mg/kg/day, however it was statistically significantly decreased only in males. Bodyweights were statistically significantly lower (9 - 14%) in females at 1000 mg/kg late in the study. Bodyweight gains were significantly decreased (compared to both controls) in males at 1000 mg/kg. No effects were observed in relation to hematology, clinical chemistry, urinalysis, ophthalmology, organ weights or pathology.) Oncogenic NOEL > 1000 mg/kg/day (There were no treatment-related tumorigenic effects at any dose.) /5,5-Dimethylhydantoin/
BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
申请人：SENOMYX, INC.
公开号：US20160376263A1
公开（公告）日：2016-12-29
The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.
[EN] METHOD AND COMPOSITION FOR WATER TREATMENT<br/>[FR] PROCÉDÉ ET COMPOSITION DE TRAITEMENT DE L'EAU
申请人：BROMINE COMPOUNDS LTD
公开号：WO2020240559A1
公开（公告）日：2020-12-03
The invention provides a method of microbial control in water comprising adding to the water one or more bromine-based biocide(s) and cis-2-decenoic acid or a salt thereof. Compositions in the form of liquid concentrates comprising bromine-based biocides and cis-2-decenoic acid or a salt thereof are also described.
The present invention provides a quaternary ammonium etidronate compound (QAE) comprising a quaternary ammonium cation and an etidronate anion, having the Formula I.
A method for the preparation of such compounds is described by reacting a quaternary ammonium salt with an etidronic acid or salt thereof. Variable ratios of each reactant may also be used to form different QAE compounds. The quaternary ammonium etidronate compounds is useful in water treatment, cosmetic, hygiene, personal care, paint, coating, wood treatment, agrochemical, antimicrobial, disinfectant, or biocidal compositions; as the compound provides high anti-corrosive and biocidal properties; and low scaling properties. A water treatment composition is also described, having a QAE compound of Formula I and a water treating biocidal agent, useful in cooling towers and other recirculating water, or recreational water system.
Concentrated aqueous bromine solutions and their preparation and use
申请人：——
公开号：US20020110603A1
公开（公告）日：2002-08-15
Described is a process of producing a concentrated liquid biocide formulation. Mixed together are (a) bromine chloride or bromine and (b) an aqueous solution of alkali metal salt of sulfamic acid having a pH of at least about 7, in amounts such that (i) the active bromine content of the solution is at least about 100,000 ppm (wt/wt), and (ii) the atom ratio of nitrogen to active bromine from (a) and (b) is greater than 1 when bromine is used and is greater than 0.93 when bromine chloride is used. Use of bromine chloride as the source of the active bromine in the process is preferred because in the resulting aqueous compositions, all of the bromine of the bromine chloride is made available as active bromine in solution. In other words, the chlorine of the bromine chloride is converted in the process to dissolved alkali metal chloride salt, thereby liberating all of the bromine in the biocidal composition as active bromine capable of providing biocidal activity.
A method of eradicating or at least substantially reducing biofilm on a surface in contact with water, or which comes in contact with water, which method comprises introducing into such water a concentrated aqueous biocidal composition formed from bromine chloride and an aqueous solution of an alkali metal salt of sulfamic acid, such composition having an active bromine content of at least about 100,000 ppm (wt/wt), a pH of at least about 7, and an atom ratio of nitrogen to active bromine of greater than 0.93.
