2-Iod-methylpyridinium | 120879-63-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Iod-methylpyridinium
• 英文别名: 2-iodo-1-methyl-pyridinium；2-Iodo-1-methylpyridin-1-ium
• CAS: 120879-63-2
• 化学式: C₆H₇IN
• 分子量: 220.033
• InChiKey: WTBMMENXWDHRKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-Iod-methylpyridinium 在 水 作用下， 生成 1-甲基-2-吡啶酮
  参考文献：
  名称：

  Accelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMP

  摘要：

  alpha-Halo and alpha-cyano pyridiniums were found to undergo facile hydrolysis, in contrast to the sluggish reactions of corresponding uracils. The greatly enhanced rates found with pyridinium compounds have indicated a possible source of the rate acceleration seen in the hydrolysis of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.108
• 作为产物：
  描述：

  2-溴吡啶 、 碘甲烷 生成 2-Iod-methylpyridinium
  参考文献：
  名称：

  Exchange Reactions of α-Halogenated Pyridines

  摘要：

  DOI：

  10.1021/jo50001a019

文献信息

• Modified Drugs for Use in Liposomal Nanoparticles
  申请人：Cullis Peter

  公开号：US20110165225A1

  公开（公告）日：2011-07-07

  Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag derivatized with a weak-base moiety that facilitates active loading of the drag through a LN transmembrane pH or ion gradient into the aqueous interior of the LN. The weak-base moiety can optionally comprise a lipophilic domain that facilitates active loading of the drag to the inner monolayer of the liposomal membrane. Advantageously, LN formulations of the drag derivatives exhibit improved solubility, reduced toxicity, enhanced efficacy, and/or other benefits relative to the corresponding free drags.

  本文提供了适用于载入脂质体纳米粒子载体的拖曳导数。在某些优选方面，这些导数包括一种难溶于水的拖曳经过弱碱基团衍生化，该弱碱基团促进通过LN跨膜pH或离子梯度将拖曳活性负载到LN的水内部。弱碱基团可以选择包括一个亲脂性域，该亲脂性域促进将拖曳活性负载到脂质体膜的内单层。优点是，与相应的自由拖曳相比，拖曳导数的LN配方表现出改善的溶解度、降低的毒性、增强的功效和/或其他益处。
• NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME
  申请人：Takemoto Naohiro

  公开号：US20100130739A1

  公开（公告）日：2010-05-27

  Provided is a compound that has the ability to promote axonal outgrowth in combination with the ability to promote angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases such as myocardial infarction and organic angina, peripheral arterial occlusive diseases such as critical limb ischemia, or after-effects of these diseases. Specifically, the compound is represented by the following formula (I): in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R 0 , R 1 and R 2 are each independently a hydrogen atom, an alkyl group, an amino group or the like; E is an oxygen atom or an —NR 8 group (wherein R 8 is an alkyl group or the like); n is an integer of 0 to 5; X and Y are each a connecting bond, a cycloalkyl group, —CO— or the like; and Q is a hydrogen atom or a phenyl group.

  提供的是一种化合物，具有促进轴突生长和促进血管生成的能力，因此可用于减少中枢神经损伤，如头部损伤和脊髓损伤，脑梗死，缺血性心脏病，如心肌梗死和器质性心绞痛，周围动脉闭塞性疾病，如严重肢体缺血或这些疾病的后遗症。具体而言，该化合物由以下公式（I）表示： 其中，Nx基团最好是含有两个氮原子的6元芳香环；R0、R1和R2分别独立地是氢原子、烷基、氨基或类似物；E是氧原子或—NR8基团（其中，R8是烷基或类似物）；n是0到5的整数；X和Y分别是连接键、环烷基、—CO—或类似物；Q是氢原子或苯基。
• A new process for carbapenem intermediates
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA

  公开号：EP0336143A1

  公开（公告）日：1989-10-11

  A novel intermediate for synthesizing 1β-alkyl-1-carbapenem, i.e., 4β-(1β-alkyl-2-carboxyprop-2-enyl)-azetidin-2-one ( II ), is prepared stereoselectively by treating 4-(leaving group substituted)azetidin-2-one ( I ) with trans-2-(leaving group substituted)methyl-3-alkylacrylic acid ( III ) and a reducing metal. wherein, R1 is hydrogen, alkyl, or substituted alkyl; R2 is optionally substituted alkyl; R3 is hydrogen or a carboxy-protecting group; and R4 and R5 each is a leaving group.

  一种合成 1β-烷基-1-碳青霉烯的新型中间体，即 4β-(1β-烷基-2-羧基丙-2-烯基)-氮杂环丁烷-2-酮 ( II )，是通过将 4-(离去基团取代)氮杂环丁烷-2-酮 ( I )与反式-2-(离去基团取代)甲基-3-烷基丙烯酸 ( III )和还原性金属进行立体选择性处理而制备的。 其中，R1 是氢、烷基或取代的烷基； R2 是任选取代的烷基 R3 是氢或羧基保护基团；以及 R4 和 R5 各为离去基团。
• Studies in the Cyanine Dye Series. XI.¹ The Merocyanines
  作者：L. G. S. Brooker、G. H. Keyes、R. H. Sprague、R. H. VanDyke、E. VanLare、G. VanZandt、F. L. White

  DOI：10.1021/ja01155a095

  日期：1951.11
• Studies in the Cyanine Dye Series. III. Improvements in the 2'-Cyanine Condensation
  作者：L. G. S. Brooker、G. H. Keyes

  DOI：10.1021/ja01315a050

  日期：1935.12