2-(3,5-dimethoxyanilino)pyridine | 1031443-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,5-dimethoxyanilino)pyridine
• 英文别名: N-(3,5-dimethoxyphenyl)pyridin-2-amine；HDiMeOap
• CAS: 1031443-22-7
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: ZSMDZVPGPABDCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  43.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3,5-dimethoxyanilino)pyridine 、 tetraacetatodiruthenium chloride 在 LiCl 、 K₂CO₃ 作用下， 以 甲苯 为溶剂， 以72%的产率得到Ru₂(2-(3,5-dimethoxy)anilinopyridinate)₄Cl
  参考文献：
  名称：

  Further molecular engineering of diruthenium-(2-anilinopyridinate) alkynyl compounds through ligand design

  摘要：

  A modified ap ligand, 2-(3,5-dimethoxyanilino) pyridine (HDiMeOap) and its diruthenium compounds Ru-2(DiMeOap)(4)Cl (1), Ru-2(DiMeOap)(4)(C CC CSiMe3) (2) and Ru-2(DiMeOap)(4)(C CC CSiMe3)(2) (3) were prepared and characterized. New compounds Ru-2(MeOap)(4)(C CC CSiMe3)(x) (x = 1, 4; 2, 5; MeOap is 2-(3-methoxyanilino) pyridinate) were prepared from the previously reported Ru-2(MeOap)(4)Cl. In addition, two related diruthenium compounds containing ferrocenyl acetylide ligand, Ru-2(MeOap)(4)(C CFc) (6) and Ru-2(ap)(4)(C CC CFc) (7), were synthesized. Molecular structures of compounds 1, 2, 6 and 7 were established using single crystal X-ray diffraction study. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2007.11.050
• 作为产物：
  描述：

  2-碘吡啶 、 3,5-二甲氧基苯胺 在 potassium tert-butylate 、 palladium diacetate 、 双(2-二苯基磷苯基)醚 作用下， 以 甲苯 为溶剂， 以85%的产率得到2-(3,5-dimethoxyanilino)pyridine
  参考文献：
  名称：

  钯（II）的9-催化的一锅合成（吡啶-2-基）通过一个汇接Ç-9H-二咔唑？^ h激活/ C ？X（X = C或N）形成过程

  摘要：

  通过同时的CH活化和钯（II）催化的N-苯基吡啶-2-胺与芳基三氟硼酸钾的交叉偶联，新的一锅合成9-（吡啶-2-基）-9 H-咔唑的方法是提出了。醋酸银和1,4-二恶烷分别被证明是最好的氧化剂和溶剂。产物收率从适中波动至优异，反应显示出足够的官能团耐受性。对苯醌是催化过程中金属转移和还原消除步骤的重要配体。第一和第二次CH活化/ C的动力学同位素效应（k H / k D）。 C或C  ñ形成步骤测量为分别2.14和1.18，。最后，基于所有实验证据提出了合理的催化机理。

  DOI：

  10.1002/chem.201101528

文献信息

• Copper anchored on phosphorus g-C₃N₄ as a highly efficient photocatalyst for the synthesis of <i>N</i>-arylpyridin-2-amines
  作者：Jia-Qi Di、Mo Zhang、Yu-Xuan Chen、Jin-Xin Wang、Shan-Shan Geng、Jia-Qi Tang、Zhan-Hui Zhang

  DOI：10.1039/d0gc03400b

  日期：——

  A copper modified phosphorus doped g-C₃N₄ (Cu/P-CN) has been prepared and identified as an efficient catalyst for the synthesis of N-arylpyridin-2-amine derivatives by the reaction of 2-aminopyridine and aryl boronic acid under the irradiation of blue light.

  一种经过铜改性的磷掺杂的g-C3N4（Cu/P-CN）已经制备并确定为一种高效催化剂，可用于在蓝光照射下通过2-氨基吡啶和芳基硼酸的反应合成N-芳基吡啶-2-胺衍生物。
• Palladium(II)-Catalyzed One-Pot Syntheses of 9-(Pyridin-2-yl)-9H-carbazoles through a Tandem CH Activation/CX (X=C or N) Formation Process
  作者：Jean-Ho Chu、Pi-Shan Lin、Ya-Ming Lee、Wei-Ting Shen、Ming-Jung Wu

  DOI：10.1002/chem.201101528

  日期：2011.11.25

  A new one‐pot synthesis of 9‐(pyridin‐2‐yl)‐9H‐carbazoles through the simultaneous CH activation and palladium(II)‐catalyzed cross‐coupling of N‐phenylpyridin‐2‐amines with potassium aryltrifluoroborates is presented. Silver acetate and 1,4‐dioxane proved to be the best oxidant and solvent, respectively. The product yields fluctuated from modest to excellent and the reaction showed sufficient functional

  通过同时的CH活化和钯（II）催化的N-苯基吡啶-2-胺与芳基三氟硼酸钾的交叉偶联，新的一锅合成9-（吡啶-2-基）-9 H-咔唑的方法是提出了。醋酸银和1,4-二恶烷分别被证明是最好的氧化剂和溶剂。产物收率从适中波动至优异，反应显示出足够的官能团耐受性。对苯醌是催化过程中金属转移和还原消除步骤的重要配体。第一和第二次CH活化/ C的动力学同位素效应（k H / k D）。 C或C  ñ形成步骤测量为分别2.14和1.18，。最后，基于所有实验证据提出了合理的催化机理。
• Further molecular engineering of diruthenium-(2-anilinopyridinate) alkynyl compounds through ligand design
  作者：Bin Xi、Guo-Lin Xu、Jie-Wen Ying、Hong-Ling Han、Antoinette Cordova、Tong Ren

  DOI：10.1016/j.jorganchem.2007.11.050

  日期：2008.4

  A modified ap ligand, 2-(3,5-dimethoxyanilino) pyridine (HDiMeOap) and its diruthenium compounds Ru-2(DiMeOap)(4)Cl (1), Ru-2(DiMeOap)(4)(C CC CSiMe3) (2) and Ru-2(DiMeOap)(4)(C CC CSiMe3)(2) (3) were prepared and characterized. New compounds Ru-2(MeOap)(4)(C CC CSiMe3)(x) (x = 1, 4; 2, 5; MeOap is 2-(3-methoxyanilino) pyridinate) were prepared from the previously reported Ru-2(MeOap)(4)Cl. In addition, two related diruthenium compounds containing ferrocenyl acetylide ligand, Ru-2(MeOap)(4)(C CFc) (6) and Ru-2(ap)(4)(C CC CFc) (7), were synthesized. Molecular structures of compounds 1, 2, 6 and 7 were established using single crystal X-ray diffraction study. (C) 2007 Elsevier B.V. All rights reserved.