2-(4-甲基-1,4-二氮杂环庚-1-基)苯甲醛 | 865203-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(4-甲基-1,4-二氮杂环庚-1-基)苯甲醛
• 英文名称: 2-(4-methyl-1,4-diazepan-1-yl)-benzaldehyde
• 英文别名: 2-(4-Methyl-1,4-diazepan-1-yl)benzaldehyde
• CAS: 865203-78-7
• 化学式: C₁₃H₁₈N₂O
• 分子量: 218.299
• InChiKey: IWGWGWJWXSGXKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Novel benayl(idene)-lactam derivatives
  申请人：Brodney A. Michael

  公开号：US20050245521A1

  公开（公告）日：2005-11-03

  The present invention relates to novel benzyl(idene)-lactam derivatives, compounds of the formula I wherein R 1 is a group of the formula G 1 or G 2 depicted below, wherein R 1 , R 3 , R 6 , R 13 X, a, n and m are as defined herein, their pharmaceutically acceptable salts, and pharmaceutical compositions which include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT 1 ) receptors, specifically, of one or both of the 5-HT 1A and 5-HT 1B receptors. The compounds of the invention are useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT 1 agonist or antagonist is indicated and have reduced potential for cardiac side effects, in particular QTc prolongation.

  本发明涉及一种新型苯甲基（亚）内酰胺衍生物，化合物的式子为I，其中R1是下面所示的式子G1或G2的基团，其中R1、R3、R6、R13、X、a、n和m的定义如本说明书所述，其药学上可接受的盐，以及包括选择性5-羟色胺1（5-HT1）受体的拮抗剂、反向激动剂和部分激动剂的药物组合物，具体来说，是5-HT1A和5-HT1B受体中的一个或两个。本发明的化合物在治疗或预防抑郁症、焦虑症、强迫症和其他需要5-HT1受体激动剂或拮抗剂的疾病方面有用，并且具有减少心脏副作用的潜力，特别是QTc延长。
• NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES
  申请人：Pfizer Products Inc.

  公开号：EP1727794B1

  公开（公告）日：2011-11-16
• SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME
  申请人：Moore Margaret D.

  公开号：US20110263484A1

  公开（公告）日：2011-10-27

  The present invention relates to single chain Fc Type III Interferon fusion proteins and methods of using same. The single chain Fc Type III Interferon fusion proteins comprise at least one Type III Interferon, two Fc regions and at least one linker, can be produced in a variety of single chain configurations, and are effector function minus or have a substantially reduced effector function.
• US7479559B2
  申请人：——

  公开号：US7479559B2

  公开（公告）日：2009-01-20