4-Hydroxy-3-(morpholinomethyl)benzoic acid hydrate | 1177335-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Hydroxy-3-(morpholinomethyl)benzoic acid hydrate
• 英文别名: 4-hydroxy-3-(morpholin-4-ylmethyl)benzoic acid;hydrate
• CAS: 1177335-94-2
• 化学式: C12H17NO5
• 分子量: 255.27
• InChiKey: PVQPDPKXACNPBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  71
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-3-(morpholinomethyl)benzoic acid hydrate 、 碘乙烷 、 溴甲苯 生成 Ethyl 4-ethoxy-3-morpholin-4-ylmethylbenzoate
  参考文献：
  名称：

  NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE

  摘要：

  本发明提供了通式(I)所表示的化合物或其药物可接受的盐，其中R1是氢或低碳基；R2是低碳基，卤代低碳基，环烷基，杂环烷基，芳基，芳基烷基，芳基烯基，芳氧基-低碳基，杂芳基，杂芳基-低碳基等；R3、R4、R5和R6均为氢、卤素、氰基、低碳基、卤代低碳基、低碳氧基、羟基、芳基等；其中至少有一个R3、R4、R5和R6不是氢。本发明的化合物(I)表现出强大的腺苷A2A受体拮抗活性，并且可用于治疗或预防由腺苷A2A受体介导的疾病，例如运动功能障碍、抑郁症、焦虑症、认知功能障碍、脑缺血性疾病、不宁腿综合征等。

  公开号：

  US20090239860A1

文献信息

• [EN] INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES<br/>[FR] INHIBITEURS DE PROTÉINES TYROSINE PHOSPHATASES
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2014055768A1

  公开（公告）日：2014-04-10

  Novel protein tyrosine phosphatase (PTP) inhibitor compounds synthesized from phosphonodifluoromethyl phenylalanine (F2Pmp) are provided. Use of these compounds for inhibiting a PTP enzyme (such as PTP-MEG2), as well as treating a disease, disorder, or condition associated with inappropriate activity of a PTP (such as type 2 diabetes), is also provided.

  提供了从磷酸二氟甲基苯丙氨酸（F2Pmp）合成的新型蛋白酪氨酸磷酸酶（PTP）抑制剂化合物。还提供了使用这些化合物来抑制PTP酶（如PTP-MEG2），以及治疗与PTP不当活性相关的疾病、紊乱或病况（如2型糖尿病）的方法。
• Inhibitors of protein tyrosine phosphatases
  申请人：Indiana University Research and Technology Corporation

  公开号：US10072043B2

  公开（公告）日：2018-09-11

  Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

  本文公开了选择性抑制 PTP 酶家族成员的化合物。合成的化合物对 TC-PTP 具有选择性抑制作用。还提供了使用这些化合物的方法和含有这些化合物的制剂。还描述了一种荧光标记组合库合成和筛选方法。还介绍了使用这些化合物影响细胞和体外酶活性的方法，以及使用这些化合物治疗人类和动物疾病的方法。
• INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES
  申请人：Zhang Zhong-Yin

  公开号：US20120088720A1

  公开（公告）日：2012-04-12

  Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
• US9217012B2
  申请人：——

  公开号：US9217012B2

  公开（公告）日：2015-12-22
• US9340574B2
  申请人：——

  公开号：US9340574B2

  公开（公告）日：2016-05-17