2-(2-Naphthyl)-1H-imidazole | 4278-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2-Naphthyl)-1H-imidazole
• 英文别名: 2-β-Naphthyl-imidazol；2-naphthalen-2-yl-1H-imidazole；2-Naphthyl imidazole；2-naphthalen-2-yl-1H-imidazole
• CAS: 4278-11-9
• 化学式: C₁₃H₁₀N₂
• 分子量: 194.236
• InChiKey: CGKIWDGOFLFAEZ-UHFFFAOYSA-N

物化性质

• 熔点：
  210-211 °C
• 沸点：
  445.0±14.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(phenyl-λ³-iodaneylidene)-cyclohexane-1,3-dione 、 2-(2-Naphthyl)-1H-imidazole 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 cesium pivalate 作用下， 以 2,2,2-三氟乙醇 为溶剂， 以66 %的产率得到6,7-dihydrobenzo[j]imidazo[1,2-f]phenanthridin-8(5H)-one
  参考文献：
  名称：

  Ru(II)-催化 2-芳基苯并咪唑与碘鎓叶立德的 C-H 官能化：直接获得桥头多环 N-杂环

  摘要：

  在此，我们公开了一种有效的钌催化的 2-芳基苯并咪唑/2-芳基咪唑与碘鎓叶立德的 C-H 官能化，产生取代的四环和五环桥头 N-杂环，其中碘鎓叶立德作为卡宾前体。碘鎓叶立德第一次通过 Ru-carbenoid 中间体进行。此外，该协议的合成效用成功地展示了克级合成和有用的合成转换。

  DOI：

  10.1021/acs.joc.2c01429
• 作为产物：
  描述：

  Benazoline 以 二甲基亚砜 为溶剂， 反应 48.0h， 以65%的产率得到2-(2-Naphthyl)-1H-imidazole
  参考文献：
  名称：

  New One-Step Synthesis of 2-Aryl-1H-Imidazoles: Dehydrogenation of 2-Aryl-Δ2-Imidazolines with Dimethylsulfoxide

  摘要：

  描述了一种新的一步法制备2-芳基-1H-咪唑的3，基于对2-芳基-Δ2-咪唑啉的DMSO脱氢作用。还开展了DMSO与10% Pd/C（在这一转化中使用的最佳催化剂）之间的比较研究。两种方法均在120°C下进行48小时。

  DOI：

  10.1055/s-2000-8237

文献信息

• [EN] IMIDAZOLINE RECEPTOR TYPE 1 LIGANDS FOR USE AS THERAPEUTICS<br/>[FR] LIGANDS DU RÉCEPTEUR AUX IMIDAZOLINES DE TYPE 1 À UTILISER EN TANT QU'AGENTS THÉRAPEUTIQUES
  申请人：RIDEOUT DARRYL

  公开号：WO2016105448A1

  公开（公告）日：2016-06-30

  This disclosure provides compounds and compositions for use as analgesics and for the treatment of various conditions, such as pain, headaches, allodynia, and fibromyalgia. The disclosure also provides compounds that are ligands, and in some embodiments, modulators (e.g., agonists), for the imidazoline receptor type 1.

  本公开提供了作为止痛剂和用于治疗各种病症的化合物和组合物，如疼痛、头痛、触痛和纤维肌痛。本公开还提供了作为嘌呤受体1的配体的化合物，有些实施例中还提供了对其的调节剂（例如，激动剂）。
• [EN] COMPOUNDS FOR USE AS PAIN THERAPEUTICS<br/>[FR] COMPOSÉS DESTINÉS À ÊTRE UTILISÉS EN TANT QU'AGENTS THÉRAPEUTIQUES CONTRE LA DOULEUR
  申请人：LEDERMAN SETH

  公开号：WO2016105449A1

  公开（公告）日：2016-06-30

  This disclosure provides compounds and compositions for use as analgesics and for the treatment of one or more conditions selected from: pain; psychic pain; psychological pain; psychiatric pain; depression; allodynia; fibromyalgia; fibromyalgia-ness; central sensitization; centralization; regional pain syndrome; temporomandibular joint syndrome (TMJ); lower back pain; interstitial cystitis; Gulf War syndrome; visceral pain; phantom limb painj.kidney stones; gout; neuropathic pain; post-herpetic neuralgia; diabetic neuropathy; sickle cell pain; priapism; nociceptive pain; post-operative pain; orthopedic injury pain; bunionectomy; dental extraction; pain after severed spinal cord injury; osteoarthritis; rheumatoid arthritis; Lyme disease; Parkinson's disease; opioid-induced constipation; an opioid withdrawal symptom; pain associated with post-traumatic stress disorder (PTSD); and combinations of any of the foregoing conditions. This disclosure also provides compounds that are ligands, and in some embodiments, modulators (e.g., agonists), for the imidazoline receptor type 1.

  本公开提供了用作镇痛剂和用于治疗以下一种或多种疾病的化合物和组合物：疼痛；心理疼痛；心理疼痛；精神疼痛；抑郁症；痛觉过敏；纤维肌痛；纤维肌痛症；中枢敏感化；中枢化；区域性疼痛综合征；颞下颌关节综合征（TMJ）；腰部疼痛；间质性膀胱炎；海湾战争综合征；内脏疼痛；幻肢疼痛；肾结石；痛风；神经性疼痛；带状疱疹后神经痛；糖尿病性神经病；镰状细胞疼痛；阴茎长时间勃起症；伤害性疼痛；术后疼痛；骨科损伤疼痛；拇外翻术；牙科拔牙；断裂脊髓损伤后疼痛；骨关节炎；类风湿关节炎；莱姆病；帕金森病；阿片类药物引起的便秘；阿片类药物戒断症状；与创伤后应激障碍（PTSD）相关的疼痛；以及上述任何疾病的组合。本公开还提供了作为咪唑啉受体类型1的配体的化合物，有些实施例中是调节剂（例如，激动剂）。
• SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  申请人：Panicker Bijoy

  公开号：US20110237633A1

  公开（公告）日：2011-09-29

  The present invention provides compounds and pharmaceutically acceptable compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which hepatocyte growth factor/scatter factor (HGF/SF) or the activities thereof, or agonists or antagonists thereof, have a therapeutically useful role.

  本发明提供化合物及其药学上可接受的组合物，以及使用它们治疗一系列疾病或病症的方法，其中包括肝细胞生长因子/散发因子（HGF/SF）或其活性，或其激动剂或拮抗剂在治疗中具有治疗作用。
• METHOD FOR PRODUCING METAL PARTICLE DISPERSION, CONDUCTIVE INK USING METAL PARTICLE DISPERSION PRODUCED BY SUCH METHOD, AND CONDUCTIVE COATING FILM
  申请人：Toyo Ink Mfg. Co., Ltd

  公开号：EP1952918A1

  公开（公告）日：2008-08-06

  Disclosed is a method for producing a metal particle dispersion wherein a metal compound is reduced by using carbodihydrazide represented by the formula (1) below or a polybasic acid polyhydrazide represented by the formula (2) below (wherein R represents an n-valent polybasic acid residue) in a liquid medium. By reducing the metal compound in the presence of a compound having a function preventing discoloration of the metal, there can be obtained a metal particle dispersion having excellent discoloration preventing properties. Metal particles produced by such methods have a uniform particle diameter and are excellent in dispersion stability. By using a conductive resin composition or conductive ink containing a metal particle dispersion obtained by such production methods, there can be formed a conductive coating film, such as a conductive circuit or an electromagnetic layer, having good characteristics.

  本发明公开了一种生产金属颗粒分散液的方法，该方法通过在液体介质中使用下式 (1) 所代表的碳二酰肼或下式 (2) 所代表的多基酸多酰肼（其中 R 代表正价多基酸残基）还原金属化合物。通过在具有防止金属褪色功能的化合物存在下还原金属化合物，可获得具有优异防褪色性能的金属颗粒分散液。通过这种方法制得的金属颗粒具有均匀的颗粒直径和出色的分散稳定性。使用含有通过这种生产方法获得的金属颗粒分散体的导电树脂组合物或导电墨水，可以形成具有良好特性的导电涂膜，例如导电电路或电磁层。
• COLORED METALLIC PIGMENT, PROCESS FOR PRODUCING THE SAME, AND COATING COMPOSITION AND COSMETIC PREPARATION COMPRISING SAID COLORED METALLIC PIGMENT
  申请人：TOYO ALUMINIUM KABUSHIKI KAISHA

  公开号：EP1990377A1

  公开（公告）日：2008-11-12

  This invention provides a colored metallic pigment, which can develop a variety of colors and varied interference colors while maintaining good lightfastness, weatherfastness and hiding power, a process for producing the same, a coating composition containing the colored metallic pigment and capable of providing a coating film having excellent finished appearance, and a cosmetic preparation containing the colored metallic pigment, having excellent hiding power, and capable of providing sharp hue. The colored metallic pigment comprises at least a metallic pigment, an amorphous silicon oxide film layer provided on the surface of the metallic pigment, a metal layer provided on the surface of the amorphous silicon oxide film layer, and metallic particles provided on the surface of the metal layer. The metallic particles are provided so as to directly cover a part of the surface of the metal layer. In the colored metallic pigment, the metal layer preferably comprises at least one metal selected from Sn, Pd, Pt and Au. The metallic particle preferably comprises at least one metal selected from Cu, Ni and Ag.

  本发明提供了一种彩色金属颜料，它能在保持良好的耐光性、耐候性和遮盖力的同时，显现出多种颜色和各种干扰色；还提供了一种生产彩色金属颜料的工艺；一种含有该彩色金属颜料并能提供具有良好成品外观的涂膜的涂料组合物；以及一种含有该彩色金属颜料、具有良好遮盖力并能提供鲜明色调的化妆品制剂。彩色金属颜料至少包括金属颜料、设置在金属颜料表面的非晶氧化硅薄膜层、设置在非晶氧化硅薄膜层表面的金属层以及设置在金属层表面的金属颗粒。金属颗粒的设置是为了直接覆盖金属层的部分表面。在有色金属颜料中，金属层最好包括至少一种选自 Sn、Pd、Pt 和 Au 的金属。金属颗粒最好包括至少一种选自铜、镍和银的金属。