4'-hexylbiphenyl-4-ol | 72057-95-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-hexylbiphenyl-4-ol
• 英文别名: 4-hydroxy-4'-hexyl biphenyl；4'-Hexyl-biphenyl-4-ol；4-(4-hexylphenyl)phenol
• CAS: 72057-95-5
• 化学式: C₁₈H₂₂O
• 分子量: 254.372
• InChiKey: DAJRNFUDNDXVPL-UHFFFAOYSA-N

物化性质

• 沸点：
  386.6±21.0 °C(Predicted)
• 密度：
  1.009±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯甲酸,二羟基- 、 4'-hexylbiphenyl-4-ol 在 N,N'-二环己基碳二亚胺 、 4-二甲氨基吡啶 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以37%的产率得到4'-hexyl-[1,1'-biphenyl]-4-yl 2,3-dihydroxybenzoate
  参考文献：
  名称：

  Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives

  摘要：

  C14 alkyl benzoate ABG001, derived from naturally occurring gentisides, was reported to exhibit neurotrophic activity which is similar to NGF (Nerve Growth Factor). In this research, ABG001 was modified by the strategy of isosteric replacement and conformational restriction with the purpose of improving the bioactivity. The cellular neurotrophic activity of those ABG001 derivatives were evaluated, among which 3-hydroxyquinolin-2-(1H)-one A3 and 4-decylphenol ester B7 displayed much better neurotrophic activity compared with ABG001, which highlights the potential of those novel scaffolds for future neurotrophic agent development.

  DOI：

  10.1016/j.bmcl.2019.126685
• 作为产物：
  描述：

  4-Hexanoyl-4'-brombiphenyl 生成 4'-hexylbiphenyl-4-ol
  参考文献：
  名称：

  FLORJANCZYI, E. B.

  摘要：

  DOI：

文献信息

• ISOCYANATE PRODUCTION PROCESS
  申请人：Shinohata Masaaki

  公开号：US20110092731A1

  公开（公告）日：2011-04-21

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention discloses a process for producing an isocyanate by subjecting a carbamic acid ester to a thermal decomposition reaction, including the steps of: recovering a low boiling point component in a form of a gaseous phase component from a thermal decomposition reaction vessel in which the thermal decomposition reaction is carried out; recovering a liquid phase component containing a carbamic acid ester from a bottom of the thermal decomposition reaction vessel; and supplying all or a portion of the liquid phase component to an upper portion of the thermal decomposition reaction vessel.

  本发明的一个目的是提供一种能够在长时间内稳定地高产且不使用光气的情况下生产异氰酸酯的方法，而不会遇到先前生产异氰酸酯时的问题。本发明公开了一种通过将氨基甲酸酯经受热分解反应来生产异氰酸酯的方法，包括以下步骤：从进行热分解反应的反应釜中回收形成气相组分的低沸点组分；从热分解反应釜底部回收含有氨基甲酸酯的液相组分；并将全部或部分液相组分供给至热分解反应釜的上部。
• PROCESS FOR PRODUCING ISOCYANATES USING DIARYL CARBONATE
  申请人：Shinohata Masaaki

  公开号：US20110054211A1

  公开（公告）日：2011-03-03

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention provides an isocyanate production process including the steps of: obtaining a reaction mixture containing an aryl carbamate having an aryl group originating in a diaryl carbonate, an aromatic hydroxy compound originating in a diaryl carbonate, and a diaryl carbonate, by reacting a diaryl carbonate and an amine compound in the presence of a reaction solvent in the form of an aromatic hydroxy compound; transferring the reaction mixture to a thermal decomposition reaction vessel; and obtaining isocyanate by applying the aryl carbamate to a thermal decomposition reaction, wherein the reaction vessel in which the reaction between the diaryl carbonate and the amine compound is carried out and the thermal decomposition reaction vessel for the aryl carbamate are different.

  本发明的一个目的是提供一种能够在生产异氰酸酯时在长时间内稳定地且高产率地生产异氰酸酯的方法，而不使用光气时遇到先前技术问题的方法。本发明提供了一种异氰酸酯生产方法，包括以下步骤：通过在反应溶剂形式的芳香羟基化合物存在下，通过反应二芳基碳酸酯和胺化合物得到含有源自二芳基碳酸酯的芳基碳酸酯、源自二芳基碳酸酯的芳香羟基化合物和二芳基碳酸酯的反应混合物；将反应混合物转移至热分解反应容器；通过将芳基碳酸酯应用于热分解反应来获得异氰酸酯，其中进行二芳基碳酸酯和胺化合物之间的反应的反应容器和用于芳基碳酸酯的热分解反应的反应容器是不同的。
• OPTICAL RECORDING MEDIUM AND COMPOUND USED FOR THE SAME
  申请人：SHIOZAKI Hiroyoshi

  公开号：US20090306376A1

  公开（公告）日：2009-12-10

  A compound comprising a ring structure including a ring composed of four carbon atoms and two nitrogen atoms and a substituted or unsubstituted amino group bonded to the ring structure.

  一种化合物，包括一个环结构，其中包括由四个碳原子和两个氮原子组成的环，以及与环结构相结合的取代或未取代的氨基团。
• Synthesis of 4-[(1R,4R)-3-Oxo-p-menthan-2-ylidenemethyl]benzoic Acid and Its Esters
  作者：T. G. Drushlyak、L. A. Kutulya、N. S. Pivnenko、V. V. Vashchenko

  DOI：10.1007/s11176-005-0283-1

  日期：2005.4

  Carbonylation of ( E )-2-(4-halobenzylidene)- p -menthan-3-ones, catalyzed by PdCl2(PPh3)2, gave a distereometric mixure of 4-[(1 R ,4 R )- and (1 R ,4 S )-3-oxo- p -menthan-2-ylidenemethyl]benzoic acids, whose reaction with phenols gave 1 R ,4 R diastereomers of the corresponding esters.

  由PdCl 2（PPh 3）2催化的（ E ）-2-（4-卤代亚苄基）- 对 - 薄荷-3-酯的羰基化 得到4-[（1 R ，4 R ）-和（ 1 R ，4 S ）-3-氧 代- 对- 薄荷基-2-亚苄基甲基]苯甲酸，其与酚的反应得到相应酯的1 R ，4 R 非对映异构体。
• Diphenylic esters exhibiting mesomorphic phases
  申请人：Thomson-CSF

  公开号：US04235736A1

  公开（公告）日：1980-11-25

  A family of diphenylic esters are disclosed, which, within certain temperature ranges exhibit mesomorphic phases, either smectic or nematic, having the general formula: ##STR1## where R.sub.1 is C.sub.n H.sub.2n+1 O or C.sub.n H.sub.2n+1 in which n is an integer of from 1 to 10, R.sub.2 is C.sub.m H.sub.2m+1 in which m is an integer of from 1 to 10, and X is Br or CN.

  本发明揭示了一类二苯酯家族，它们在特定温度范围内表现出介向相，可以是液晶相或向列相，具有以下一般式：##STR1## 其中R.sub.1是C.sub.n H.sub.2n+1 O或C.sub.n H.sub.2n+1，其中n是1到10的整数，R.sub.2是C.sub.m H.sub.2m+1，其中m是1到10的整数，X是Br或CN。