(4S)-2-diethylamino-4-phenyl-1,3,2-dioxaphospholan | 1341180-90-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4S)-2-diethylamino-4-phenyl-1,3,2-dioxaphospholan
• 英文别名: (4S)-N,N-diethyl-4-phenyl-1,3,2-dioxaphospholan-2-amine
• CAS: 1341180-90-2
• 化学式: C₁₂H₁₈NO₂P
• 分子量: 239.254
• InChiKey: VBSNLGPOHGMVTE-ZGTOLYCTSA-N

物化性质

• 沸点：
  247.6±20.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (S)-(+)-1-苯基-1,2-乙二醇 、 六乙基亚磷酸胺 以 甲苯 为溶剂， 反应 1.0h， 以74%的产率得到(4S)-2-diethylamino-4-phenyl-1,3,2-dioxaphospholan
  参考文献：
  名称：

  Phosphoramidites based on phenyl-substituted 1,2-diols as ligands in palladium-catalyzed asymmetric allylations: the contribution of steric demand and chiral centers to the enantioselectivity

  摘要：

  A small family of readily available phosphoramidite ligands, including compounds with P*-stereocenters, has been prepared from phenyl-substituted 1,2-diols as simple and cheap starting materials. Using these ligands, up to 84% ee was achieved in Pd-catalyzed asymmetric allylic substitution. The influence of structural modules such as asymmetric atoms and steric demand on the enantioselectivity is discussed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.122