2-<<2-<<(4-methyl-5-imidazolyl)methyl>thio>ethyl>amino>nicotinic acid | 85608-29-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-<<2-<<(4-methyl-5-imidazolyl)methyl>thio>ethyl>amino>nicotinic acid
• 英文别名: 2-[2-(5-methyl-4-imidazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid；2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]pyridine-3-carboxylic acid
• CAS: 85608-29-3
• 化学式: C₁₃H₁₆N₄O₂S
• 分子量: 292.362
• InChiKey: SZYGUCAYLZXSSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氯烟酸 、 2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 2-<<2-<<(4-methyl-5-imidazolyl)methyl>thio>ethyl>amino>nicotinic acid
  参考文献：
  名称：

  2-[2-Thiazolyl or 2-guanidino-4-thiazolyl methylthioethyl(or

  摘要：

  这项发明涉及2-氨基-3-羟基和3-羧基吡啶衍生物，其中氨基被甲硫乙基、丁基或氧丙基基团取代，带有一个端部杂环基团。这些化合物具有组胺H.sub.2 -拮抗活性。该发明的一个具体化合物是2-[2-(2-瓜地尼基-4-噻唑基甲硫基)乙基]氨基吡啶-3-羧酸。

  公开号：

  US04439437A1

文献信息

• 2-(furanyl alkylamino or thienyl alkylamino or
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04652572A1

  公开（公告）日：1987-03-24

  This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal heterocyclic group. The compounds have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(2-guanidino-4-thiazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid.

  本发明涉及2-氨基-3-羟基和3-羧基吡啶衍生物，其中氨基基团被甲硫基乙基，丁基或氧丙基取代，并带有一个末端杂环基团。这些化合物具有组胺H.sub.2-拮抗活性。本发明的一个具体化合物是2-[2-(2-胍基-4-噻唑基甲硫基)乙基]氨基吡啶-3-羧酸。
• 2-(Imidazolyl alkylamino)-3-carboxy(or hydroxy)-pyridines
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04547512A1

  公开（公告）日：1985-10-15

  This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal heterocyclic group. The compounds have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(2-guanidino-4-thiazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid.

  本发明涉及2-氨基-3-羟基和3-羧基吡啶衍生物，其中氨基基团被甲硫基乙基、丁基或氧丙基取代，这些基团带有一个末端杂环基团。这些化合物具有组胺H.sub.2-拮抗活性。本发明的一个具体化合物是2-[2-(2-鸟氨酸-4-噻唑基甲硫基)乙基]氨基吡啶-3-羧酸。
• Zwitterionic analogs of cimetidine as H2 receptor antagonists
  作者：Rodney C. Young、C. Robin Ganellin、Michael J. Graham、Robert C. Mitchell、Michael L. Roantree、Zev Tashma

  DOI：10.1021/jm00390a006

  日期：1987.7

  A series of analogues of the H2 receptor histamine antagonist cimetidine have been synthesized in which the dipolar cyanoguanidine group has been replaced by a number of zwitterionic moieties. Although none of the compounds is more effective than cimetidine in blocking histamine-stimulated tachycardia on the isolated guinea pig atrium, the activities of most of the compounds possessing rigid dipoles can be accounted for on the basis of dipole orientation relative to the common side chain and by considering the active species in each case to be the zwitterion. These findings are in general agreement with those found for analogues having conjugated groups as dipoles.
• YOUNG R. C.; GANELLIN C. R.; GRAHAM M. J.; MITCHELL R. C.; ROANTREE M. L.+, J. MED. CHEM., 30,(1987) N 7, 1150-1156
  作者：YOUNG R. C.、 GANELLIN C. R.、 GRAHAM M. J.、 MITCHELL R. C.、 ROANTREE M. L.+

  DOI：——

  日期：——
• US4439437A
  申请人：——

  公开号：US4439437A

  公开（公告）日：1984-03-27