pyridine-2-sulfonic acid (5-methyl-isoxazol-3-yl)-amide | 1241663-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: pyridine-2-sulfonic acid (5-methyl-isoxazol-3-yl)-amide
• 英文别名: N-(5-methyl-1,2-oxazol-3-yl)pyridine-2-sulfonamide
• CAS: 1241663-07-9
• 化学式: C₉H₉N₃O₃S
• 分子量: 239.255
• InChiKey: RRBYZJFGDBXGLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  93.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-氨基-5-甲基异恶唑 、 吡啶-2-磺酰氯 在 吡啶 作用下， 以91%的产率得到pyridine-2-sulfonic acid (5-methyl-isoxazol-3-yl)-amide
  参考文献：
  名称：

  Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors

  摘要：

  Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic study on the subtype- and species-selectivity of MetAP inhibitors that require the binding of an auxiliary metal ion. This includes, in particular, compounds based on the benzimidazole pharmacophore, but also hydroxyquinoline and picolinic acid derivatives. Our data indicates that a significant degree of selectivity can be attained with metal-dependent MetAP inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.093

文献信息

• Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors
  作者：Markus A. Altmeyer、Aline Marschner、Rolf Schiffmann、Christian D. Klein

  DOI：10.1016/j.bmcl.2010.05.093

  日期：2010.7

  Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic study on the subtype- and species-selectivity of MetAP inhibitors that require the binding of an auxiliary metal ion. This includes, in particular, compounds based on the benzimidazole pharmacophore, but also hydroxyquinoline and picolinic acid derivatives. Our data indicates that a significant degree of selectivity can be attained with metal-dependent MetAP inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.