N-(4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)phenyl)picolinamide | 1372892-90-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)phenyl)picolinamide
• 英文别名: N-[4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]phenyl]pyridine-2-carboxamide
• CAS: 1372892-90-4
• 化学式: C₂₂H₁₄ClN₃O₃
• 分子量: 403.824
• InChiKey: URHMSTCCEYHTGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(4-nitrophenyl)picolinamide 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 0.03h， 生成 N-(4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)phenyl)picolinamide
  参考文献：
  名称：

  [EN] AMINONAPTHOQUINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR BLOCKING UBIQUITINATION-PROTEASOME SYSTEM IN DISEASES
  [FR] COMPOSÉ AMINO-NAPTHOQUINONE ET COMPOSITION PHARMACEUTIQUE BLOQUANT LE SYSTÈME UBIQUITINE-PROTÉASOME DANS DES MALADIES

  摘要：

  这项发明涉及一种新的化合物，具有低细胞毒性，用于阻断疾病中的泛素化-蛋白酶体系统。因此，这些化合物可用于治疗包括但不限于癌症、神经退行性疾病、炎症性疾病、自身免疫性疾病和代谢性疾病在内的疾病。

  公开号：

  WO2017014788A1

文献信息

• AMINONAPTHOQUINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR BLOCKING UBIQUITINATION-PROTEASOME SYSTEM IN DISEASES
  申请人：Bridgent Biotechnology Inc.

  公开号：US20200148643A1

  公开（公告）日：2020-05-14

  The invention relates to new compounds with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.

  该发明涉及一种在疾病中阻断泛素化-蛋白酶体系统的低细胞毒性新化合物。因此，这些化合物可用于治疗包括但不限于癌症、神经退行性疾病、炎症性疾病、自身免疫性疾病和代谢性疾病在内的疾病。
• Aminonapthoquinone compounds and pharmaceutical composition for blocking ubiquitination-proteasome system in diseases
  申请人：TAIPEI MEDICAL UNIVERSITY

  公开号：US10577328B2

  公开（公告）日：2020-03-03

  The invention relates to a compound of formula (I) with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, multiple myeloma, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.

  本发明涉及一种式 (I) 的化合物 具有低细胞毒性，可用于阻断疾病中的泛素化-蛋白酶体系统。因此，这些化合物可用于治疗各种疾病，包括但不限于多发性骨髓瘤、癌症、神经退行性疾病、炎症性疾病、自身免疫性疾病和代谢性疾病。
• Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors
  作者：Kai Xu、Zhiyan Xiao、Yan Bo Tang、Li Huang、Chin-Ho Chen、Emika Ohkoshi、Kuo-Hsiung Lee

  DOI：10.1016/j.bmcl.2012.02.086

  日期：2012.4

  Fourteen naphthoquinone derivatives (1-14) were designed based on a putative proteasome inhibitor PI-083. These compounds were synthesized and evaluated against A549, DU145, KB, and KBvin tumor cell lines. Six compounds (2, 4, 8, 9, 10, and 13) showed antiproliferative activities comparable to that of PI-083. Among them, compound 8 was confirmed as a 20S proteasome inhibitor in both in vitro and cell-based assays. These findings endorse further optimization efforts based on this structural phenotype to develop potential anticancer drug candidates. (C) 2012 Elsevier Ltd. All rights reserved.
• [EN] AMINONAPTHOQUINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR BLOCKING UBIQUITINATION-PROTEASOME SYSTEM IN DISEASES<br/>[FR] COMPOSÉ AMINO-NAPTHOQUINONE ET COMPOSITION PHARMACEUTIQUE BLOQUANT LE SYSTÈME UBIQUITINE-PROTÉASOME DANS DES MALADIES
  申请人：UNIV TAIPEI MEDICAL

  公开号：WO2017014788A1

  公开（公告）日：2017-01-26

  The invention relates to new compounds with low cytotoxicity for blocking the ubiquitination- proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.

  这项发明涉及一种新的化合物，具有低细胞毒性，用于阻断疾病中的泛素化-蛋白酶体系统。因此，这些化合物可用于治疗包括但不限于癌症、神经退行性疾病、炎症性疾病、自身免疫性疾病和代谢性疾病在内的疾病。