N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide | 303049-18-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide
• CAS: 303049-18-5
• 化学式: C₁₄H₁₅NO₃S
• 分子量: 277.344
• InChiKey: GLDVWHQVGHPIFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide 在 silver carbonate 作用下， 以 甲苯 为溶剂， 反应 0.5h， 生成 3,5-dimethyl-N-phenylsulfonyl-1,4-benzoquinonimine
  参考文献：
  名称：

  Synthesis of 5-substituted 2,3-dihydrobenzofurans in a one-pot oxidation/cyclization reaction

  摘要：

  Variously substituted 2,3-dihydrobenzofurans have been synthesized according :o a sequential one-pot oxidation/cyclization procedure between para-aminophenol derivatives and an azadiene. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.020
• 作为产物：
  描述：

  3,5-二甲基-4-氨基苯酚 、 苯磺酰氯 在 碳酸氢钠 作用下， 以 水 为溶剂， 以89%的产率得到N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide
  参考文献：
  名称：

  Avdeenko, Russian Journal of Organic Chemistry, 2000, vol. 36, # 4, p. 522 - 527

  摘要：

  DOI：

文献信息

• Avdeenko; Menafova; Zhukova, Russian Journal of Organic Chemistry, 1998, vol. 34, # 2, p. 210 - 220
  作者：Avdeenko、Menafova、Zhukova

  DOI：——

  日期：——
• Avdeenko, Russian Journal of Organic Chemistry, 2000, vol. 36, # 4, p. 522 - 527
  作者：Avdeenko

  DOI：——

  日期：——
• Halogenation of N-substituted para-quinone monoimine and para-quinone monooxime esters: V. Chlorination and bromination of N-arylsulfonyl-1,4-benzoquinone monoimines dialkyl-substituted in the quinoid ring
  作者：A. P. Avdeenko、S. A. Konovalova

  DOI：10.1134/s1070428006050058

  日期：2006.5

  The direction of halogen addition to N-arylsulfonyl-1,4-benzoquinone monoimines dialkyl-substituted in the quinoid ring is governed by the steric factors: the size and position of the substituent, the halogen volume, and the position of the substituent at the nitrogen. The first stage of halogenation of N-arylsulfonyl-4-aminophenols with two alkyl substituents in the phenylsulfonyl ring largely occurs as electrophilic substitution.
• Synthesis of 5-substituted 2,3-dihydrobenzofurans in a one-pot oxidation/cyclization reaction
  作者：Fabien Baragona、Thierry Lomberget、Christian Duchamp、Natali Henriques、Eugenio Lo Piccolo、Patrizia Diana、Alessandra Montalbano、Roland Barret

  DOI：10.1016/j.tet.2011.09.020

  日期：2011.11

  Variously substituted 2,3-dihydrobenzofurans have been synthesized according :o a sequential one-pot oxidation/cyclization procedure between para-aminophenol derivatives and an azadiene. (C) 2011 Elsevier Ltd. All rights reserved.