N,α-dimethyl-2-phenylethylamine oxalate | 175166-06-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,α-dimethyl-2-phenylethylamine oxalate
• 英文别名: methamphetamine oxalate；N-methyl-1-phenylpropan-2-amine;oxalic acid
• CAS: 175166-06-0
• 化学式: C₂H₂O₄*C₁₀H₁₅N
• 分子量: 239.271
• InChiKey: QBHXOBRIGUCDQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.99
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  DL-甲基苯丙胺 、 草酸 以 乙醇 为溶剂， 反应 0.5h， 以4.65 g的产率得到N,α-dimethyl-2-phenylethylamine oxalate
  参考文献：
  名称：

  Synthesis of 2-Arylethylamines by the Curtius Rearrangement

  摘要：

  2-Arylethylamine derivatives were synthesized using the Curtius reaction and with three different methods of preparing the acyl azide functional group. Carbamates derived from isocyanate were convenient protecting groups for alkylation of amines. Starting from benzaldehyde, amphetamine was prepared in three steps through an oxazolidin-2-one intermediate in 62% overall yield.

  DOI：

  10.1080/00397910903097302

文献信息

• New amphetamine derivatives, antibodies against them and pharmaceutical compositions containing them
  申请人：Drug Abuse Sciences, Inc.

  公开号：EP1331219A1

  公开（公告）日：2003-07-30

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo to amphetamines are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. A therapeutic composition containing the hapten-carrier conjugate is useful in the treatment of addiction to amphetamines. Passive immunization using antibodies raised against conjugates of the instant invention also is disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs for treatment of amphetamine abuse.

  本发明公开了能够在体内引起抗卟胺类化合物抗体的卟胺类化合物载体共轭物。还公开了制备卟胺类化合物载体共轭物和治疗组合物的方法。含有卟胺类化合物载体共轭物的治疗组合物可用于治疗对卟胺类化合物的成瘾。本发明还公开了使用针对本发明共轭物所产生的抗体进行被动免疫的方法。该治疗组合物适用于与其他传统药物联合治疗卟胺类药物滥用。
• [EN] ANTIBODIES AGAINST AND COMPOSITIONS CONTAINING NEW AMPHETAMINE DERIVATIVES<br/>[FR] ANTICORPS LUTTANT CONTRE DE NOUVEAUX DERIVES D'AMPHETAMINE ET COMPOSITIONS CONTENANT DE NOUVEAUX DERIVES D'AMPHETAMINE
  申请人：DRUGABUSE SCIENCES INC

  公开号：WO2003061595A2

  公开（公告）日：2003-07-31

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo to amphetamines are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. A therapeutic composition containing the hapten-carrier conjugate is useful in the treatment of addiction to amphetamines. Passive immunization using antibodies raised against conjugates of the instant invention also is disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs for treatment of amphetamine abuse.
• Synthesis of 2-Arylethylamines by the Curtius Rearrangement
  作者：Matthias Schulze

  DOI：10.1080/00397910903097302

  日期：2010.4.26

  2-Arylethylamine derivatives were synthesized using the Curtius reaction and with three different methods of preparing the acyl azide functional group. Carbamates derived from isocyanate were convenient protecting groups for alkylation of amines. Starting from benzaldehyde, amphetamine was prepared in three steps through an oxazolidin-2-one intermediate in 62% overall yield.