2-Oxo-propane-1-sulfonic acid ((R)-1-phenyl-ethyl)-amide | 205679-08-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Oxo-propane-1-sulfonic acid ((R)-1-phenyl-ethyl)-amide
• 英文别名: 2-oxo-N-[(1R)-1-phenylethyl]propane-1-sulfonamide
• CAS: 205679-08-9
• 化学式: C₁₁H₁₅NO₃S
• 分子量: 241.311
• InChiKey: WETIOZCPJBDBSJ-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Oxo-propane-1-sulfonic acid ((R)-1-phenyl-ethyl)-amide 、 碘甲烷 在 lithium diisopropyl amide 作用下， 生成 3-Oxo-butane-2-sulfonic acid ((R)-1-phenyl-ethyl)-amide 、 2-Oxo-propane-1-sulfonic acid methyl-((R)-1-phenyl-ethyl)-amide
  参考文献：
  名称：

  Synthesis and reactivity of N-alkyl-2-oxoalkanesulfonamides

  摘要：

  A series of N-alkyl-2-oxoalkanesulfonamides have been synthesized by reacting silyl enol ethers with N-alkyl-sulfamoyl chlorides. Their reactivity towards electrophiles was investigated in order to explore the regio-and stereoselectivity of the process. 2-Oxoalkanesulfonamides were used to prepare 5-(methylsulfamoyl)-1,4-dihydropyridines derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00093-3
• 作为产物：
  描述：

  2-(三甲基硅氧基)丙烯 、 N-[(1R)-1-phenylethyl]sulfamoyl chloride 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以58%的产率得到2-Oxo-propane-1-sulfonic acid ((R)-1-phenyl-ethyl)-amide
  参考文献：
  名称：

  Synthesis and reactivity of N-alkyl-2-oxoalkanesulfonamides

  摘要：

  A series of N-alkyl-2-oxoalkanesulfonamides have been synthesized by reacting silyl enol ethers with N-alkyl-sulfamoyl chlorides. Their reactivity towards electrophiles was investigated in order to explore the regio-and stereoselectivity of the process. 2-Oxoalkanesulfonamides were used to prepare 5-(methylsulfamoyl)-1,4-dihydropyridines derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00093-3

文献信息

• Synthesis and reactivity of N-alkyl-2-oxoalkanesulfonamides
  作者：Juan A. Vega、Ramón Alajarín、Juan J. Vaquero、Julio Alvarez-Builla

  DOI：10.1016/s0040-4020(98)00093-3

  日期：1998.4

  A series of N-alkyl-2-oxoalkanesulfonamides have been synthesized by reacting silyl enol ethers with N-alkyl-sulfamoyl chlorides. Their reactivity towards electrophiles was investigated in order to explore the regio-and stereoselectivity of the process. 2-Oxoalkanesulfonamides were used to prepare 5-(methylsulfamoyl)-1,4-dihydropyridines derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.