N,N'-bis[(S)-1-isobutyl-2-hydroxyethyl] sulfamide | 915697-13-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: N,N'-bis[(S)-1-isobutyl-2-hydroxyethyl] sulfamide
• 英文别名: (2S)-2-[[(2S)-1-hydroxy-4-methylpentan-2-yl]sulfamoylamino]-4-methylpentan-1-ol
• CAS: 915697-13-1
• 化学式: C₁₂H₂₈N₂O₄S
• 分子量: 296.431
• InChiKey: RYGNBFQUIRCVTJ-RYUDHWBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N,N'-bis[(S)-1-isobutyl-2-hydroxyethyl] sulfamide 在 磺酰氯 、 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 18.0h， 生成 N,N'-bis[(S)-2-isobutylaziridin-1-yl] sulfone
  参考文献：
  名称：

  Efficient Synthesis of Chiral 1,1′‐Sulfonyl Bisaziridines

  摘要：

  An efficient three-step synthesis of chiral 1,10-(sulfonyl)bisaziridines is described. Preparation of these compounds was carried out easily starting from N,N'-sulfonyl bis-(alpha-L-aminoester) to afford the title compounds in very good yields. These 1,1'-(sulfonyl) bisaziridines can constitute interesting synthetic building blocks.

  DOI：

  10.1080/00397910600639802
• 作为产物：
  描述：

  N,N'-sulfonyl bis-L-leucine dimethyl ester 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 以83%的产率得到N,N'-bis[(S)-1-isobutyl-2-hydroxyethyl] sulfamide
  参考文献：
  名称：

  Efficient Synthesis of Chiral 1,1′‐Sulfonyl Bisaziridines

  摘要：

  An efficient three-step synthesis of chiral 1,10-(sulfonyl)bisaziridines is described. Preparation of these compounds was carried out easily starting from N,N'-sulfonyl bis-(alpha-L-aminoester) to afford the title compounds in very good yields. These 1,1'-(sulfonyl) bisaziridines can constitute interesting synthetic building blocks.

  DOI：

  10.1080/00397910600639802

文献信息

• Efficient Synthesis of Chiral 1,1′‐Sulfonyl Bisaziridines
  作者：Nawel Khettache、Amel Bendjeddou、Malika Berredjem、Zine Regainia、Veronique Montero、Chantal Menut、Nour‐Eddine Aouf、Jean‐Yves Winum

  DOI：10.1080/00397910600639802

  日期：2006.8

  An efficient three-step synthesis of chiral 1,10-(sulfonyl)bisaziridines is described. Preparation of these compounds was carried out easily starting from N,N'-sulfonyl bis-(alpha-L-aminoester) to afford the title compounds in very good yields. These 1,1'-(sulfonyl) bisaziridines can constitute interesting synthetic building blocks.