N8-(5-(diethylamino)pentan-2-yl)-2,3-di(thiophen-2-yl)pyrido[2,3-b]pyrazine-6,8-diamine | 1347750-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶吡嗪类
• 英文名称: N8-(5-(diethylamino)pentan-2-yl)-2,3-di(thiophen-2-yl)pyrido[2,3-b]pyrazine-6,8-diamine
• 英文别名: N8-[4-(diethylamino)-1-methyl-butyl]-2,3-bis(2-thienyl)pyrido[2,3-b]pyrazine-6,8-diamine；8-N-[5-(diethylamino)pentan-2-yl]-2,3-dithiophen-2-ylpyrido[2,3-b]pyrazine-6,8-diamine
• CAS: 1347750-01-9
• 化学式: C₂₄H₃₀N₆S₂
• 分子量: 466.674
• InChiKey: NTPYCLUDUDQHIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-氨基-5-二乙基氨基戊烷 在 乙醇 、 氢气 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 43.0h， 生成 N8-(5-(diethylamino)pentan-2-yl)-2,3-di(thiophen-2-yl)pyrido[2,3-b]pyrazine-6,8-diamine
  参考文献：
  名称：

  Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors

  摘要：

  A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H37Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.09.062

文献信息

• Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors
  作者：Bini Mathew、Shefali Srivastava、Larry J. Ross、William J. Suling、E. Lucile White、Lisa K. Woolhiser、Anne J. Lenaerts、Robert C. Reynolds

  DOI：10.1016/j.bmc.2011.09.062

  日期：2011.12

  A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H37Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity. (C) 2011 Elsevier Ltd. All rights reserved.