N-ethyl-N-phenyl-phthalamic acid | 514823-42-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-N-phenyl-phthalamic acid
• 英文别名: N-Aethyl-N-phenyl-phthalamidsaeure；Phthalsaeure-mono-aethylanilid；N-Aethyl-phthalanilsaeure；2-[Ethyl(phenyl)carbamoyl]benzoic acid
• CAS: 514823-42-8
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: PUIAQBCFFSVWNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-ethyl-N-phenyl-phthalamic acid 在 sodium hydroxide 作用下， 220.0 ℃ 、980.59 kPa 条件下， 生成 N-乙基苯胺
  参考文献：
  名称：

  DE526881

  摘要：

  公开号：
• 作为产物：
  描述：

  苯酐 、 N-乙基苯胺 生成 N-ethyl-N-phenyl-phthalamic acid
  参考文献：
  名称：

  Piutti, Gazzetta Chimica Italiana, 1883, vol. 13, p. 558

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES<br/>[FR] INHIBITEURS DE PROTÉINES TYROSINE PHOSPHATASES
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2014055768A1

  公开（公告）日：2014-04-10

  Novel protein tyrosine phosphatase (PTP) inhibitor compounds synthesized from phosphonodifluoromethyl phenylalanine (F2Pmp) are provided. Use of these compounds for inhibiting a PTP enzyme (such as PTP-MEG2), as well as treating a disease, disorder, or condition associated with inappropriate activity of a PTP (such as type 2 diabetes), is also provided.

  提供了从磷酸二氟甲基苯丙氨酸（F2Pmp）合成的新型蛋白酪氨酸磷酸酶（PTP）抑制剂化合物。还提供了使用这些化合物来抑制PTP酶（如PTP-MEG2），以及治疗与PTP不当活性相关的疾病、紊乱或病况（如2型糖尿病）的方法。
• Derivatives of 6-Aminopenicillanic Acid. III. Reactions with N-Substituted Phthalamic Acids
  作者：Y. G. Perron、W. F. Minor、L. B. Crast、A. Gourevitch、J. Lein、L. C. Cheney

  DOI：10.1021/jm01240a015

  日期：1962.9.1
• [EN] INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES<br/>[FR] INHIBITEURS DES PROTÉINE-TYROSINE PHOSPHATASES
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2010118241A2

  公开（公告）日：2010-10-14

  Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC- PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
• [EN] COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE ACTIVITY<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR POTENTIALISER L'ACTIVITÉ IMMUNITAIRE
  申请人：KUMQUAT BIOSCIENCES INC

  公开号：WO2021119554A1

  公开（公告）日：2021-06-17

  The present disclosure provides compositions and methods for enhancing immunity. The compositions and methods are particularly useful for potentiating immune response of a lymphoid cell. The compositions and methods are also applicable for treating cancer and other diseases.