3,5-Dihydroxy-2-(hydroxymethyl)benzoic acid | 918668-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Dihydroxy-2-(hydroxymethyl)benzoic acid
• CAS: 918668-58-3
• 化学式: C₈H₈O₅
• 分子量: 184.149
• InChiKey: ZCLQMXZHBQFNLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲酰基-3,5-二羟基苯甲酸 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.67h， 以79%的产率得到3,5-Dihydroxy-2-(hydroxymethyl)benzoic acid
  参考文献：
  名称：

  Synthesis of diverse analogues of Oenostacin and their antibacterial activities☆

  摘要：

  Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC50 ranging from 0.49 to 0.67 mu M as compared to Oenostacin (EC50 = 0.12 mu M). (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.09.034

文献信息

• Synthesis of diverse analogues of Oenostacin and their antibacterial activities☆
  作者：Vandana Srivastava、Mahendra P. Darokar、Atiya Fatima、J.K. Kumar、Chinmay Chowdhury、Hari Om Saxena、Gaurav R. Dwivedi、Kunal Shrivastava、Vivek Gupta、S.K. Chattopadhyay

  DOI：10.1016/j.bmc.2006.09.034

  日期：2007.1.1

  Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC50 ranging from 0.49 to 0.67 mu M as compared to Oenostacin (EC50 = 0.12 mu M). (c) 2006 Elsevier Ltd. All rights reserved.